MCT3 抗体 (C-Term, Intracellular)
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Quick Overview for MCT3 抗体 (C-Term, Intracellular) (ABIN7581969)
抗原
See all MCT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 421-434, C-Term, Intracellular
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原理
- A Rabbit Polyclonal Antibody to Monocarboxylate Transporter 3
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序列
- (C)RSAEGGASDP EDVE
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交叉反应 （详细）
- Not recommended for human samples.
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预测反应
- Mouse - identical
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产品特性
- Anti-MCT3 Antibody (ABIN7581969) is a highly specific antibody directed against an epitope of the rat Monocarboxylate transporter 3. The antibody can be used in western blot analysis. It has been designed to recognize MCT3 from rat and mouse samples. The antibody is unlikely to recognize the protein from human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RSAEGGASDPEDVE, corresponding to amino acid residues 421-434 of rat MCT3
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亚型
- IgG
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anti-Monocarboxylate Transporter 3 (MCT3) (AA 432-504) antibody
MCT3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Monocarboxylate Transporter 3 (MCT3) antibodyMCT3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Monocarboxylate Transporter 3 (MCT3) (AA 251-300) antibodyMCT3 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Monocarboxylate Transporter 3 (MCT3) (AA 466-493), (C-Term) antibodyMCT3 适用: 人 WB 宿主: 兔 Polyclonal RB31404 unconjugated
anti-Monocarboxylate Transporter 3 (MCT3) (Middle Region) antibodyMCT3 适用: 人, 大鼠, 小鼠, Cow, 豚鼠, 犬, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- MCT3 (Monocarboxylate Transporter 3 (MCT3))
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别名
- SLC16A8
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背景
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Synonyms: Monocarboxylate transporter 3, Monocarboxylic acid transporter 3, SLC16A8
Description: Proton-linked monocarboxylate transporters (MCTs) are a family of highly homologous trans-membrane symporters, involved in the transportation of monocarboxylic acids across the plasma membrane such as: lactate, pyruvate, branched-chain oxoacids derived from leucine, valine, and isoleucine, ketone bodies, acetoacetate, β-hydroxybutyrate and acetate. Thus, MCTs play an important role in metabolic communication among cells and in mammalian metabolism.MCT3 is encoded by the Slc16a8 gene and contains at least nine members in humans1. Structurally, MCTs have 12 transmembrane spanning domains with cytoplasmic NH2- and COOH-terminals. The COOH-terminal regions are not well conserved among the MCTs isoforms while the membrane spanning domains share the greatest sequence identity3,4. Findings suggest that the N-terminal domain is more important for energy coupling, membrane insertion and correct structure maintenance, whereas the C-terminal domain is more important for the determination of substrate specificity1.MCT3 is expressed in the retinal pigment epithelium, preferentially expressed in the basolateral membrane in the adult and in choroid plexus epithelium where it plays a role in regulating pH and lactate concentrations in the outer retina. Reduced levels of MCT3 in response to trauma or disease could contribute to pathologic changes in the retina2,3. MCT3 can form a heteromeric complex with the accessory protein CD147, an immunoglobulin superfamily protein.
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基因ID
- 65200
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UniProt
- O70461
抗原
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