RGMA 抗体 (Extracellular)
Quick Overview for RGMA 抗体 (Extracellular) (ABIN7581951)
抗原
See all RGMA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 138-154, Extracellular
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原理
- A Rabbit polyclonal antibody to RGMA (extracellular).
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序列
- (C)ERSDSPEI(S)HYEKSFHK
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特异性
- Extracellular, N-terminus (pro-domain).
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预测反应
- Mouse,human,rat - 16 out of 17 amino acid identical
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产品特性
- Anti-RGMA (extracellular) Antibody (ABIN7581951) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize RGMA from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ERSDSPEI(S)HYEKSFHK, corresponding to amino acid residues 138 - 154 of mouse RGMA
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亚型
- IgG
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anti-RGM Domain Family, Member A (RGMA) (AA 153-408) antibody
RGMA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RGM Domain Family, Member A (RGMA) (AA 326-423) antibodyRGMA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6D7 unconjugated
anti-RGM Domain Family, Member A (RGMA) antibodyRGMA 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Antigen preadsorption control: 1 μg peptide per 1 μg antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- RGMA (RGM Domain Family, Member A (RGMA))
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别名
- RGMA
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背景
- Repulsive Guidance Molecule A, RGM Domain Family Member A, Repulsive Guidance Molecule BMP Co-Receptor A, RGMa,Repulsive Guidance Molecule A (RGMA) is a member of the RGM family, which also includes RGMb (DRAGON) and RGMc (hemojuvelin). It is a glycosylphosphatidylinositol (GPI)-anchored protein characterized by a von Willebrand factor type D domain and a GPI-anchor, facilitating membrane association and soluble forms1,2. This dual functional nature enables RGMA to act both as a localized, membrane-bound signal and as a long-range soluble signaling molecule, expanding its versatility in biological processes3. RGMA plays a critical role in axonal guidance, neuronal differentiation, and survival, primarily by interacting with the receptor neogenin. This interaction also regulates apoptosis via Akt pathway dephosphorylation. RGMA acts as a Bone Morphogenetic Protein (BMP) co-receptor, enhancing Smad-dependent signaling pathways2,3. It is expressed in the central nervous system (CNS), particularly in retinal ganglion cells, midbrain dopaminergic neurons, and the spinal cord, with roles extending from embryonic development to adult neuroplasticity1,3,4. RGMA is implicated in several biological processes, including axonal regeneration and inhibition, neuronal survival, and inflammatory responses. Pathological upregulation of RGMA has been linked to neurodegenerative disorders like multiple sclerosis (MS) and Parkinson's disease. In MS, RGMA inhibits axonal regeneration, while in Parkinson's, it contributes to dopaminergic neuron degeneration1,4,5. Research areas benefiting from RGMA immunodetection include neuroregeneration, CNS repair, and therapeutic strategies for neurodegenerative diseases4,5.
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基因ID
- 244058
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UniProt
- Q6PCX7
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途径
- Tube Formation
抗原
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