PTGER2 抗体 (Extracellular)
Quick Overview for PTGER2 抗体 (Extracellular) (ABIN7581947)
抗原
See all PTGER2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 287-299, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Prostanoid EP2 Receptor
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序列
- (C)DETSSRKEKW DLR
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特异性
- 3rd extracellular loop
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预测反应
- Mouse - 12,13 amino acid residues identical, human - 11
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产品特性
- Anti-Prostaglandin E Receptor EP2/PTGER2 (extracellular) Antibody (ABIN7581947) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize EP2 receptor from rat, mouse, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DETSSRKEKWDLR, corresponding to amino acid residues 287-299 of rat prostanoid EP2 receptor
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亚型
- IgG
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anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) antibody
PTGER2 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (AA 271-358) antibodyPTGER2 适用: 人, 小鼠, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) antibodyPTGER2 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 8D8 unconjugated Recombinant Antibody
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (N-Term) antibodyPTGER2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (C-Term) antibodyPTGER2 适用: 人, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (Cytoplasmic Domain) antibodyPTGER2 适用: 人, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (Extracellular Domain) antibodyPTGER2 适用: 人, 小鼠, Bat, Cow, Pig ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (Extracellular Domain) antibodyPTGER2 适用: 人, 猴, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (C-Term) antibodyPTGER2 适用: 人, 小鼠, 大鼠, 犬 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2) (AA 271-358) antibody (AbBy Fluor® 647)PTGER2 适用: 人, 小鼠, 绵羊 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 647
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:100
Application Dilutions Western blot wb: 1:500
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- PTGER2 (Prostaglandin E Receptor 2 (Subtype EP2), 53kDa (PTGER2))
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别名
- PTGER2
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背景
- Prostaglandin E2 receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor,Prostaglandin E2 (PGE2) is involved in a number of physiological and pathophysiological events in many tissues throughout the body1. The physiological actions of PGE2 are mediated through its interaction with cell surface prostaglandin E receptors.There are three pharmacologically defined subtypes of the EP receptor, EP1, EP2, and EP3, and these subtypes are suggested to be different in their signal transduction2. These receptors belong to the G-protein coupled receptor (GPCR) superfamily. Like all members they have seven transmembrane domains with an extracellular N-terminal tail and an intracellular C-terminus. The EP2 receptor is expressed in the vasculature, the gastrointestinal tract, kidney and also in the ciliary muscles of the eye3.PGE2 is known to play a central role in the pathophysiology of inflammation in synergy with other proinflammatory mediators. PGE2 inhibits the function and the proliferation of T cells and the histamine release from mast cells by increasing the intracellular level of cAMP4.The EP2 subtype is thought to be in part responsible for vasodilation, oedema formation, hyperanalgesia, modulation of the immune system, and the breakdown of bone and cartilage associated with disorders such as rheumatoid arthritis5.
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基因ID
- 81752
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UniProt
- Q62928
抗原
-
