Plexin A4 抗体 (Extracellular)
Quick Overview for Plexin A4 抗体 (Extracellular) (ABIN7581945)
抗原
See all Plexin A4 (PLXNA4) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 201-215, Extracellular
-
原理
- A Rabbit Polyclonal antibody to Plexin-A4 (extracellular)
-
序列
- (C)RKLTKNSEAD GMFAY
-
特异性
- Extracellular, N-term.
-
预测反应
- Human,Rat - identical
-
产品特性
- Anti-Plexin-A4 (extracellular) Antibody (ABIN7581945) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize Plexin-A4 from mouse, rat and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)RKLTKNSEADGMFAY, corresponding to amino acid residues 201 - 215 of mouse Plexin-A4
-
亚型
- IgG
-
-
anti-Plexin A4 (PLXNA4) antibody
PLXNA4 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Plexin A4 (PLXNA4) (AA 24-522) antibodyPLXNA4 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- Plexin A4 (PLXNA4)
-
别名
- PLXNA4
-
背景
- PLXNA4,The plexin family are transmembrane proteins which are classified into four subfamilies: plexin -A, B, C and D. The plexins serve as a receptor for seamaphorins (Sema), axon guidance molecules involved in cellular processes such as axon pruning and repulsion, regulation of cell migration, vascular remodeling and more1. All family members consist of a Sema domain at the N-terminus responsible for Sema binding. In addition, plexins have PSI and IPT (Integrin, Plexin, and Transcription factor) domains, which connect to the transmembrane (TM) helix. Moreover, intracellular region of all plexins contains a membrane proximal juxtamembrane region (JM), a Rho GTPase-binding domain (RBD), and GTPase Activating Protein (GAP) domain2.Plexin-A4 acts as a receptor for the secreted semaphorins Sema3A and Sema6A in the central nervous system, and mediates axon repulsion and synaptic plasticity. Moreover, genome-wide significant association study (GWAS) on humans, has identified that several single nucleotide polymorphisms (SNPs) in PLXNA4 can increase the risk of Alzheimer's disease (AD) 3,4.In the immune system, Plexin-A4 has been implicated in macrophage Toll-like receptor (TLR)-mediated signaling in sepsis, negative regulation of T-cell mediated immune responses in cancer5.
-
基因ID
- 243743
-
UniProt
- Q80UG2
-
途径
- Regulation of Cell Size
抗原
-
