OPN3 抗体 (Extracellular)
Quick Overview for OPN3 抗体 (Extracellular) (ABIN7581929)
抗原
See all OPN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 180-194, Extracellular
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原理
- A Rabbit Polyclonal antibody to Opsin 3 (extracellular)
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序列
- (C)DIHGLG(S)TVDWRSKD
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特异性
- Extracellular, 2nd loop.
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预测反应
- Mouse - 14 out of 15 amino acid identical Rat,human - 12 out of 15 amino acid identical
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产品特性
- Anti-Opsin 3 (extracellular) Antibody (ABIN7581929) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize Opsin 3 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DIHGLG(S)TVDWRSKD, corresponding to amino acid residues 180 - 194 of mouse Opsin 3
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亚型
- IgG
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anti-Opsin 3 (OPN3) (Internal Region) antibody
OPN3 适用: 人, 大鼠, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (AA 313-402) antibodyOPN3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (Internal Region) antibodyOPN3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (AA 300-400) antibodyOPN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (C-Term) antibodyOPN3 适用: 人, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Opsin 3 (OPN3) (AA 161-210) antibodyOPN3 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- OPN3 (Opsin 3 (OPN3))
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别名
- OPN3
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背景
- OPN3, Encephalopsin, Panopsin,Opsin 3 (OPN3), also known as encephalopsin or panopsin, is a member of the opsin family, which are light-sensitive G protein-coupled receptors (GPCRs) primarily known for their role in vision.1-3Opsins are found throughout the animal kingdom and while most vertebrates have a similar repertoire of 6-20 genes, mammals most commonly have eight opsins, although humans have nine.1-3Unlike Rhodopsin (or Opsin 2), the founding member of the opsin family, which is located in the retina and is essential for vision in low-light conditions, Opsin 3 has a more widespread expression pattern and functions that extend beyond traditional visual processing.1-3Opsin 3 is expressed in various tissues, including the brain, skin, testes, and lungs, among others.1-3Opsin 3 is abundantly expressed in the skin (a major light sensing organ). The function of Opsin 3 in photodetection and photosensitivity is not clear, but it appears to be based in a light-independent manner and through the interaction with MC1R, another GPCR that is crucial for the regulation of pigmentation in the skin and hair. 4An intriguing role for Opsin 3 was described in relation to regulation of energy metabolism. Opsin 3 was shown to regulate thermogenesis and lipolysis via a blue-light dependent mechanism in adipose tissue. 5As mentioned above, Opsin 3 is extensively expressed in several brain regions, including cortex, hippocampus and hypothalamus. Opsin 3 expression in brain regions associated with circadian rhythms, such as the hypothalamus, may suggest a possible role in regulating these rhythms. This connection could influence sleep-wake cycles and other circadian-related functions. In addition, Opsin 3 expression in regions like the hippocampus, a key area for memory and learning, indicates it might play a role in neural development or synaptic plasticity. This could have implications for learning, memory, and other cognitive functions. 4,6Finally, Opsin 3 has been detected in several cells of the immune system including T-cells and macrophages, implying that immune responses could be potentially regulated through light-related mechanisms.2,7
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基因ID
- 13603
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UniProt
- Q9WUK7
抗原
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