NPTX2 抗体 (Secreted)
Quick Overview for NPTX2 抗体 (Secreted) (ABIN7581924)
抗原
See all NPTX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 186-198, Secreted
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原理
- A Rabbit Polyclonal antibody to Neuronal Pentraxin 2 (NPTX2)
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序列
- (C)HNETSAHRQK TES
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特异性
- Secreted
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预测反应
- Human - identical,rat - 12 out of 13 amino acid residues identical
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产品特性
- Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (ABIN7581924) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX2 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HNETSAHRQKTES, corresponding to amino acid residues 186 - 198 of mouse NPTX2
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亚型
- IgG
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anti-Neuronal Pentraxin II (NPTX2) (AA 160-189) antibody
NPTX2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB08971 unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 309-338) antibodyNPTX2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 179-228) antibodyNPTX2 适用: 人, 小鼠, 犬, 豚鼠, Cow, 马, Pig, 兔, 斑马鱼, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 71-120) antibodyNPTX2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 111-367) antibodyNPTX2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 85-326) antibodyNPTX2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 1-431) antibodyNPTX2 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 1-431) antibodyNPTX2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (AA 90-240) antibodyNPTX2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Pentraxin II (NPTX2) (N-Term) antibodyNPTX2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NPTX2 (Neuronal Pentraxin II (NPTX2))
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别名
- NPTX2
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背景
- Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP,Neuronal pentraxin 2 (NP2), also known as NPTX2, NP-II, and neuronal activity-regulated pentraxin (Narp), is a calcium-dependent lectin secreted protein member of the pentraxin family involved in synaptic plasticity and excitatory homeostasis.1,2NP2 is part of the neuronal pentraxin family that includes two other members: Neuronal Pentraxin 1 (NP1) and Neuronal Pentraxin Receptor (NPTXR). The pentraxin superfamily members are arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain 2,3.NP2 is widely expressed in the brain, especially in the hippocampus, dentate gyrus, cerebellum, and cerebral cortex regions, as well as in the testis, pancreas, liver, heart, and skeletal muscle.2,3NP2 interacts with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are crucial for excitatory neurotransmission in the brain. By binding to AMPA receptors, NP2 influences their trafficking and localization at synapses, affecting the strength of excitatory synaptic transmission 2,3.Given its presence in brain regions associated with learning and memory, alterations in NP2 levels or function have been implicated in cognitive processes. Dysregulation of NP2 has been observed in various neurological disorders, suggesting its potential importance in maintaining cognitive function.4-6Abnormalities in NP2 expression have been linked to neurodegenerative disorders, including Alzheimer's disease. Changes in NP2 levels may contribute to synaptic dysfunction and cognitive decline observed in these conditions.4-6
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基因ID
- 53324
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UniProt
- O70340
抗原
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