NPBWR1 抗体 (Intracellular)
Quick Overview for NPBWR1 抗体 (Intracellular) (ABIN7581920)
抗原
See all NPBWR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 145-158, Intracellular
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原理
- A Rabbit Polyclonal antibody to NPBWR1 receptor
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序列
- (C)ESRRVSGRTY GAAR
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特异性
- Intracellular, 2nd loop.
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交叉反应 （详细）
- The antibody is specific for NPBWR1, it will not recognize the human only receptor NPBWR2.
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预测反应
- Rat - identical, human - 12 out of 14 amino acid residues identical
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产品特性
- Anti-NPBWR1 Antibody (ABIN7581920) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPBWR1 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ESRRVSGRTYGAAR, corresponding to amino acid residues 145 - 158 of mouse NPBWR1
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亚型
- IgG
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anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Extracellular Domain) antibody
NPBWR1 适用: 人, 大鼠 IHC (p), IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Cytoplasmic Domain) antibodyNPBWR1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Cytoplasmic Domain) antibodyNPBWR1 适用: 人 ELISA, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (C-Term) antibodyNPBWR1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) antibodyNPBWR1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))
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别名
- NPBWR1
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背景
- Neuropeptides B/W Receptor Type 1, G Protein-Coupled Receptor 7, GPR7,Neuropeptides B/W receptor type 1 (NPBWR1), also known as G-protein coupled receptor 7 (GPR7), is a member of the G-protein coupled receptor (GPCR) superfamily.NPBWR1 mediates the biological activities of Neuropeptide B (NPB) and neuropeptide W (NPW) that are structurally and functionally related endogenous neuropeptides. In humans, a second receptor termed NPBWR2 or GPR8, has been identified, however, NPBWR2 is absent in rodents.1,2NPBWR1 is expressed in the central nervous system (CNS) and in peripheral tissues. In the brain expression of NPBWR1 is found in several regions including hypothalamus, hippocampus and amygdala. Indeed, the distribution of NPBWR1 and its ligands in brain is in accordance to their established functions in appetite control and feeding behavior, as well as locomotion, analgesia and stress response.2,3Several studies have pointed to the role of NPBWR1 in pain modulation. Interestingly, NPBWR1 has structural similarities with the opioid receptors and in fact, it binds non-selective opioid ligands such as β-endorphin.3 It has been suggested, that a combination therapies of morphine (an opioid receptor ligand) and NPBWR1 agonists could provide a new avenue to treat inflammatory and neuropathic pain with less risk of adverse effects. 4In the periphery, NPBWR1 may be involved in energy homeostasis by regulating insulin secretion from pancreatic β cells and regulating white and brown adipose tissue. 3
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基因ID
- 226304
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UniProt
- P49681
抗原
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