NEGR1 抗体 (Extracellular)
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Quick Overview for NEGR1 抗体 (Extracellular) (ABIN7886646)
抗原
See all NEGR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular
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原理
- A Rabbit polyclonal antibody to NEGR1 (extracellular).
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序列
- (C)HISPSAKPFE NGQYLD
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预测反应
- Human,Rat - identical
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产品特性
- Anti-NEGR1 (extracellular) Antibody (ABIN7581917) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize NEGR1 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HISPSAKPFENGQYLD, corresponding to amino acid residues 168 -183 of mouse NEGR1
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亚型
- IgG
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anti-Neuronal Growth Regulator 1 (NEGR1) (AA 1-196) antibody
NEGR1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) antibodyNEGR1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (AA 228-327) antibodyNEGR1 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (AA 228-327) antibodyNEGR1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (N-Term) antibodyNEGR1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (Internal Region) antibodyNEGR1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (Internal Region) antibodyNEGR1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (AA 71-120) antibodyNEGR1 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) antibodyNEGR1 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Neuronal Growth Regulator 1 (NEGR1) (AA 189-218) antibodyNEGR1 适用: 人 WB 宿主: 兔 Polyclonal RB36589 unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NEGR1 (Neuronal Growth Regulator 1 (NEGR1))
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别名
- NEGR1
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背景
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Synonyms: Neuronal Growth Regulator 1, IgLON Family Member 4, IGLON4
Description: Neuronal growth regulator 1 (NEGR1), also known as neurotractin or Kilon, is a member of the immunoglobulin superfamily's IgLON subgroup. Structurally, IgLON proteins share three Ig-like C2-type domains and are anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor1,2. These proteins are implicated in neural development, supporting cellular interactions, neurite outgrowth, and synaptic formation3,4. NEGR1 is predominantly expressed in brain tissue, especially in the cerebral cortex, hippocampus, and hypothalamus. At the cellular level, it localizes to neuronal cell membranes where it regulates neurite extension and synapse stabilization1,5. NEGR1 activity is regulated through interaction with signaling molecules such as leukemia inhibitory factor receptor (LIFR), which affects downstream factors like lipocalin-2 (Lcn2) that are vital for neurogenesis and affective behaviors3. Functionally, NEGR1 modulates cell adhesion and neurite growth, processes essential for the proper development of neural circuits. It plays roles in both physiological and pathological states, for example, it is linked to hippocampal neurogenesis and synaptic plasticity, influencing behaviors related to anxiety and depression3,5. Dysfunctions in NEGR1 are associated with obesity, learning difficulties, psychiatric disorders, and mood dysregulation. Knockout studies in mice reveal that the loss of NEGR1 leads to reduced body mass, anxiety-like behaviors, and impaired neurogenesis2,4.
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基因ID
- 320840
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途径
- Feeding Behaviour
抗原
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