L1CAM 抗体 (Extracellular, N-Term)
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Quick Overview for L1CAM 抗体 (Extracellular, N-Term) (ABIN7581912)
抗原
See all L1CAM 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 653-667, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to L1CAM (extracellular)
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序列
- (C)EDKEMAPEKW YSLGK
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预测反应
- Mouse,rat - 14 out of 15 amino acid residues identical
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产品特性
- Anti-L1CAM (extracellular) Antibody (ABIN7581912) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize L1CAM from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EDKEMAPEKWYSLGK, corresponding to amino acid residues 653 - 667 of human L1CAM
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亚型
- IgG
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anti-L1 Cell Adhesion Molecule (L1CAM) antibody
L1CAM 适用: 人, 犬, 猴 WB, FACS, IF 宿主: 小鼠 Monoclonal 2G9 unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) antibodyL1CAM 适用: 人, 猴 WB, FACS 宿主: 小鼠 Monoclonal 2A5 unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) (AA 1143-1257) antibodyL1CAM 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) (AA 20-197) antibodyL1CAM 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5C6A10 unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) antibodyL1CAM 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) (AA 526-690) antibodyL1CAM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) (AA 995-1119) antibodyL1CAM 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-L1 Cell Adhesion Molecule (L1CAM) (AA 550-900) antibodyL1CAM 适用: 人 IHC 宿主: 小鼠 Monoclonal 171R unconjugated Recombinant Antibody
anti-L1 Cell Adhesion Molecule (L1CAM) antibodyKD Validated L1CAM 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3510 unconjugated Recombinant Antibody
anti-L1 Cell Adhesion Molecule (L1CAM) antibodyKD Validated L1CAM 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB3690 unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- L1CAM (L1 Cell Adhesion Molecule (L1CAM))
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别名
- L1CAM
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背景
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Synonyms: L1 Cell Adhesion Molecule, Neural Cell Adhesion Molecule L1, NCAM-L1, CAML1, CD171
Description: L1 cell adhesion molecule (L1CAM), also known as neural cell adhesion molecule L1 (NCAM-L1) and CD171, is a transmembrane glycoprotein of the immunoglobulin (Ig) superfamily involved in neuronal structure and function and cell adhesion dynamics.1L1CAM is composed of 1257 amino acids comprising six Ig-like domains, five fibronectin type III repeats, a transmembrane region, and a highly conserved cytoplasmic tail. L1CAM is the prototype member of the L1-family of closely related neural cell adhesion molecules (CAMs). It has been shown that L1CAM is regulated by the Wnt/β-catenin signaling pathway, which is involved in maintaining cellular homeostasis, and nuclear β-catenin co-localizes with L1CAM staining in tumor sections. It has also been shown that in endometrial carcinomas, L1CAM is regulated by two distinct promoter regions and that SLUG, a zinc-finger transcription factor, is important for this regulation.1L1CAM plays a crucial role in neuronal migration, axon growth, and synapse formation in the developing nervous system. Dysfunction of L1CAM leads to clinically variable neurological disorders that are jointly referred to as L1 syndrome, including hydrocephalus, mental disabilities, aphasia, spastic paraplegia, and adducted thumbs.2Although L1CAM was originally identified as a neuronal cell adhesion molecule, it has also been shown to be an essential component for disseminated cancer cells from breast, lung, kidney, and colorectal carcinomas to initiate proliferation in the brain, lung, liver, and bone. L1CAM is used to adhere and spread on the surface of blood capillaries and to activate mechanotransduction-sensitive transcription factors, which are required for the initiation of metastatic outgrowth in perivascular sites.3L1CAM has been found in exosomes and extracellular vesicles in various contexts. For example, in the context of cancer, L1CAM-positive exosomes have been implicated in promoting cancer cell migration and invasion. Exosomes carrying L1CAM can interact with other cells, such as immune cells or endothelial cells, and potentially promote tumor progression and metastasis 4,5.Furthermore, in the nervous system, L1CAM is expressed in neurons and plays a role in axon guidance and neural cell adhesion. Exosomes containing L1CAM may be involved in interneuronal communication and potentially influence neural development and plasticity 4,5.
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基因ID
- 3897
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UniProt
- P32004
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途径
- Synaptic Membrane
抗原
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