Serotonin Receptor 6 抗体 (Extracellular)
Quick Overview for Serotonin Receptor 6 抗体 (Extracellular) (ABIN7581901)
抗原
See all Serotonin Receptor 6 (HTR6) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 167-181, Extracellular
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原理
- A Rabbit Polyclonal antibody to 5HT6 Receptor (HTR6) (extracellular).
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序列
- (C)HELGKARTPA PGQ(S)R
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特异性
- Extracellular, 2nd loop.
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预测反应
- Rat - 14 out of 15 amino acid residues identical Mouse - 13 out of 15 amino acid residues identical The antibody is not recommended for human samples
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产品特性
- Anti-5HT6 Receptor (HTR6) (extracellular) Antibody (ABIN7581901) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize 5HT6 from mouse and rat samples. The antibody is not recommended for human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)HELGKARTPAPGQ(S)R, corresponding to amino acid residues 167 - 181 of rat HTR6
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亚型
- IgG
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anti-Serotonin Receptor 6 (HTR6) (C-Term) antibody
HTR6 适用: 人, 大鼠, 犬, Hamster, 马, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 6 (HTR6) (Internal Region) antibodyHTR6 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 6 (HTR6) (Internal Region) antibodyHTR6 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 6 (HTR6) (Internal Region) antibodyHTR6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 6 (HTR6) (Internal Region) antibodyHTR6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Serotonin Receptor 6 (HTR6) (C-Term) antibodyHTR6 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:400
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Serotonin Receptor 6 (HTR6)
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别名
- HTR6
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背景
- 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, 5-HT-6, 5HT6R,5HT6 also known as 5-Hydroxytryptamine Receptor 6, Serotonin Receptor 6, or 5-HT-6, is a member of the serotonin (5-HT) family of receptors that comprises 14 members, classified into 7 distinct families (5HT1 to 5HT7). With the exception of 5HT3 that is a ligand-gated channel, all other family members are G protein-coupled receptors (GPCRs) 1,2.The 5HT6 receptor is almost exclusively present in the central nervous system and is distributed in various brain regions, including the striatum, nucleus accumbens, hippocampus, thalamus, cerebellum, dentate gyrus, olfactory tubercles, amygdala, and cerebral cortex.1,2,5Based on the unique expression pattern of 5HT6 in the brain, research on the 5HT6 receptor has suggested its involvement in various neurological and psychiatric conditions, including mood disorders, schizophrenia, cognitive function and Alzheimer's disease 1,2,5. Indeed several antagonists of 5HT6 receptor have been examined in the context of schizophrenia3, Alzheimer's disease4 and cognitive impairment 5.
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基因ID
- 64354
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UniProt
- P31388
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途径
- JAK/STAT Signaling
抗原
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