GPRC5A 抗体 (Intracellular)
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Quick Overview for GPRC5A 抗体 (Intracellular) (ABIN7581891)
抗原
See all GPRC5A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 296-310, Intracellular
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原理
- A Rabbit Polyclonal Antibody to GPRC5A
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序列
- (C)ENRAYSQEEI TQGFE
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特异性
- Intracellular, C-terminus.
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预测反应
- Mouse,rat - 14,15 identical.
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产品特性
- Anti-GPRC5A Antibody (ABIN7581891) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot. It has been designed to recognize GPRC5A from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)ENRAYSQEEITQGFE, corresponding to amino acid residues 296 - 310 of human GPRC5A
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亚型
- IgG
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anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (Cytoplasmic Domain) antibody
GPRC5A 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (AA 258-357) antibodyGPRC5A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) antibodyGPRC5A 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (Transmembrane Domain) antibodyGPRC5A 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (AA 1-357) antibodyGPRC5A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (AA 1-33) antibodyGPRC5A 适用: 人 ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (Internal Region) antibodyGPRC5A 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (C-Term) antibodyGPRC5A 适用: 人, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (C-Term) antibodyGPRC5A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A) (C-Term) antibodyGPRC5A 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Antigen preadsorption control: 1 μg peptide per 1 μg antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPRC5A (G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A))
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别名
- GPRC5A
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背景
- Retinoic Acid-Induced Gene 1 Protein, RAIG1, Retinoic Acid Induced 3, RAI3, G Protein-Coupled Receptor Class C Group 5 Member A,GPRC5A, also known as retinoic acid-induced gene 3 (RAI3) or RAIG1, is a member of the orphan G-protein-coupled receptor (GPCR) family C, subgroup 5. GPRC5A is predominantly localized to the plasma membrane and intracellular compartments such as the endoplasmic reticulum and Golgi apparatus1,2. This protein is widely expressed in normal tissues, including the lung, liver, and kidney, and in cancers such as prostate, colon, and breast. At the cellular level, GPRC5A is found in epithelial cells and within the tumor microenvironment1,3. It is transcriptionally regulated by retinoic acid (RA) via retinoic acid response elements in its promoter region, linking its expression to RA signaling pathways2,4. GPRC5A plays diverse roles in both tumor suppression and promotion, depending on the context. In lung tissue, it acts as a tumor suppressor, with its absence associated with increased lung tumor incidence in murine models2. Conversely, in colon and prostate cancers, overexpression of GPRC5A is associated with poor prognosis, promoting cell proliferation and migration, and correlating with advanced disease stages and metastasis3-5. In vitro studies demonstrate that GPRC5A enhances colony formation and cell proliferation, while its knockdown reduces these activities and induces cell cycle arrest at the G2/M phase3-5. Aberrant GPRC5A function has been implicated in various diseases. Its suppression in lung cancer highlights its protective role, whereas its overexpression in colon, prostate, and breast cancers indicates its involvement in tumor progression and recurrence. High cytoplasmic expression of GPRC5A in colon cancer correlates with increased recurrence risk and poor survival2,3,5.
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基因ID
- 9052
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UniProt
- Q8NFJ5
抗原
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