GPR26 抗体 (Intracellular)
Quick Overview for GPR26 抗体 (Intracellular) (ABIN7581889)
抗原
See all GPR26 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 315-329, Intracellular
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原理
- A Rabbit Polyclonal antibody to GPR26
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序列
- (C)RRSIHSVGLT GDSHS
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特异性
- Intracellular, C-terminus.
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预测反应
- Mouse,Human - 14,15 identical
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产品特性
- Anti-GPR26 Antibody (ABIN7581889) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR26 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RRSIHSVGLTGDSHS, corresponding to amino acid residues 315 -329 of rat GPR26
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亚型
- IgG
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anti-G Protein-Coupled Receptor 26 (GPR26) (Internal Region) antibody
GPR26 适用: 人, 犬, Cow, 马, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 26 (GPR26) (Extracellular Domain) antibodyGPR26 适用: 人, 犬, Pig, 马, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 26 (GPR26) (Cytoplasmic Domain) antibodyGPR26 适用: 人, 犬, Pig, 马, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 26 (GPR26) (C-Term) antibodyGPR26 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Antigen preadsorption control: 1 μg peptide per 1 μg antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPR26 (G Protein-Coupled Receptor 26 (GPR26))
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别名
- GPR26
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背景
- G Protein-Coupled Receptor 26,GPR26, also known as G protein-coupled receptor 26, is part of the extensive G protein-coupled receptor (GPCR) superfamily, characterized by seven transmembrane domains¹. These receptors primarily mediate cellular responses to various extracellular signals, such as hormones and neurotransmitters, by coupling with intracellular G proteins, leading to signal transduction cascades1,3. GPR26 exhibits high basal activity, stimulating cyclic AMP (cAMP) production in an agonist-independent manner3. It is predominantly expressed in the central nervous system, particularly in the hypothalamus, amygdala, cortex, and striatum3,5. Cellularly, it localizes to neurons and is involved in central nervous system processes2,4. Functionally, GPR26 modulates energy balance via hypothalamic AMPK signaling and influences mood regulation by phosphorylating CREB in the amygdala2,5. p>Inactivation of GPR26 in animal models demonstrates its role in obesity, anxiety, and depression. In vitro, its loss enhances hypothalamic activity, causing hyperphagia and metabolic dysregulation, while in vivo, it leads to reduced phosphorylated CREB levels, contributing to anxiety and depression-like behaviors2,5. Aberrant GPR26 function is implicated in glioblastomas due to epigenetic silencing, linking it to tumorigenesis1. It is also associated with neurodegenerative diseases, where it participates in intranuclear inclusion formation in neurons and glial cells4. Research on GPR26 benefits areas like neuropsychiatric disorders, metabolic diseases, cancer, and neurodegeneration, where its detection and functional studies may inform therapeutic developments1,3.
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基因ID
- 192153
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UniProt
- Q9QXI3
抗原
-
