GPR158 抗体 (Intracellular)
Quick Overview for GPR158 抗体 (Intracellular) (ABIN7581886)
抗原
See all GPR158 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 960-974, Intracellular
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原理
- A Rabbit Polyclonal antibody to GPR158 receptor
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序列
- (C)EPRKPQKSGI MKQQR
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特异性
- Intracellular, C-terminus.
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预测反应
- Human - identical,Rat - 14 out of 15 amino acid residues identical
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产品特性
- Anti-GPR158 Antibody (ABIN7581886) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize GPR158 from rat, mouse and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)EPRKPQKSGIMKQQR, corresponding to amino acid residues 960 - 974 of mouse GPR158
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亚型
- IgG
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anti-G Protein-Coupled Receptor 158 (GPR158) (AA 882-1003) antibody
GPR158 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 158 (GPR158) (N-Term) antibodyGPR158 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 158 (GPR158) (AA 1-50) antibodyGPR158 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 158 (GPR158) (N-Term) antibodyGPR158 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 158 (GPR158) (N-Term) antibodyGPR158 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 158 (GPR158) (AA 1120-1169) antibodyGPR158 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPR158 (G Protein-Coupled Receptor 158 (GPR158))
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别名
- GPR158
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背景
- Probable G-protein coupled receptor 158, Metabotropic Glycine Receptor, mGlyR,G protein-coupled receptor 158 (GPR158) is a protein that belongs to the G protein-coupled receptor (GPCR) superfamily. GPR158 was identified as an orphan receptor and a member of Class C GPCRs. 1Class C GPCRs are obligatory dimers and are characterized by a large N- terminus extracellular ligand-binding domain linked to the seven-transmembrane (7TM) domain, and a large intracellular C-terminus domain. Members of Class C GPCRs include metabotropic glutamate receptors (mGluRs) and GABA(B) receptors, among others.1,2GPR158 is highly expressed in the central nervous system (CNS), particularly in the hippocampus, cortex, midbrain, and cerebellum. Indeed, GPR158 has been linked to affective disorders, such as memory loss, cognitive diseases and depression. 2Recently, osteocalcin (OCN) has been proposed as a putative ligand for GPR158. OCN is is a protein primarily produced by osteoblasts and appears to mediate its memory and cognitive regulation properties, through GPR158.3,4Lately however, GPR158 was identified as the long sought metabotropic receptor mediating the slow neuromodulatory effects of glycine (Gly) and in analogy to the well-known metabotropic glutamate receptors (mGluRs), it has been named as mGlyR.5,6The recognition that GPR158 function is central for cognition and affective states, may pave the way for the development of novel antidepressant drugs targeting GPR158.Finally, GPR158 expression has been found to be elevated in several types of cancer including glioma, prostate and ovarian cancinomas.2
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基因ID
- 241263
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UniProt
- Q8C419
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途径
- Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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