GPR108 抗体 (Extracellular)
Quick Overview for GPR108 抗体 (Extracellular) (ABIN7581883)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 124-137, Extracellular
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原理
- A Rabbit Polyclonal antibody to GPR108 (extracellular)
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序列
- (C)KDLQVQVRKY GEQK
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特异性
- Extracellular, N-term.
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预测反应
- Rat,human - identical
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产品特性
- Anti-GPR108 (extracellular) Antibody (ABIN7581883) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize GPR108 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KDLQVQVRKYGEQK, corresponding to amino acid residues 124 - 137 of mouse GPR108
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亚型
- IgG
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anti-G Protein-Coupled Receptor 108 (GPR108) (Cytoplasmic Domain) antibody
GPR108 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (Cytoplasmic Domain) antibodyGPR108 适用: 人, 小鼠, 大鼠, Cow, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (C-Term) antibodyGPR108 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (AA 101-200) antibodyGPR108 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (AA 33-260) antibodyGPR108 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (Internal Region) antibodyGPR108 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (AA 174-223) antibodyGPR108 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 108 (GPR108) (AA 155-204) antibodyGPR108 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPR108 (G Protein-Coupled Receptor 108 (GPR108))
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别名
- GPR108
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背景
- G-Protein Coupled Receptor 108, Lung Seven Transmembrane Receptor 2, LUSTR2,G protein coupled receptors (GPCR or GPR) comprise a large superfamily of receptors characterized by a seven transmembrane domain structure and an ability to activate intracellular transducer G proteins. Over 800 GPCRs in five main families have been identified in eukaryotes on the basis of genomic sequence analysis1,2. These receptors can be activated by hormones, neurotransmitters, odorants, light, or pheromones. Whereas the endogenous agonist is remains unclear or in dispute2.GPCRs mediated the signaling of extracellular stimuli to intracellular responses via activation of heterotrimeric G proteins and their subsequent interaction with effector proteins. GPCRs have been implicated in a number of physiological functions including development of anxiety, behavior, homeostasis, cognition, appetite, and drug addiction3.The GPCR family contains a diverse group of cell-surface mediators of signal transduction, its size exceeding other cell-surface protein receptors including the tyrosine kinase receptors, guanylyl cyclase receptors and ligand-gated ion channels4.GPR108 (LUSTR2), has a large extracellular domain of an amino-terminal hydrophobic signal peptide sequence, and a carboxy-terminal seven-transmembrane domain5. Previous studies showed that GPR108 is linked to nuclear factor κB (NF-κB) signaling6 and regulates and inflammatory immune response and cancer signaling7.Recently, GPR108 has been identified as a highly conserved cellular entry factor for Adeno-associated virus (AAV), a widely used and clinically approved gene therapy vector8.
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基因ID
- 78308
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UniProt
- Q91WD0
抗原
-
