FLRT3 抗体 (Extracellular, N-Term)
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Quick Overview for FLRT3 抗体 (Extracellular, N-Term) (ABIN7581871)
抗原
See all FLRT3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 387-401, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to FLRT3 (extracellular)
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序列
- (C)KQPDIKNPKL TKDQR
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预测反应
- Mouse - 14 out of 15 amino acids identical,Human - 13 out of 15 amino acids identical
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产品特性
- Anti-FLRT3 (extracellular) Antibody (ABIN7581871) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize FLRT3 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KQPDIKNPKLTKDQR, corresponding to amino acid residues 387 - 401 of rat FLRT3
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亚型
- IgG
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anti-Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3) (AA 415-490) antibody
FLRT3 适用: 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3) (AA 209-264) antibodyFLRT3 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3) (AA 375-425) antibodyFLRT3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3) (AA 29-152) antibodyFLRT3 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:200
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3))
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别名
- FLRT3
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背景
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Synonyms: Fibronectin Leucine Rich Transmembrane Protein 3, Leucine-rich repeat transmembrane protein FLRT3
Description: The leucine-rich repeat (LRR) superfamily is a diverse protein family that consist of leucine-rich domains (LRR domains). The LRR domain is known to regulate protein-protein interaction or cell adhesion. A Large portion of LRR proteins mediate the differentiation and development of nervous tissues1.The fibronectin leucine-rich transmembrane 3 (FLRT3) protein play an important function during excitatory neuron development including neuron migration, axon guidance, or synapse formation2. FLRT3 gene is encoding single pass transmembrane domain with one extracellular LRR domain and a juxtamembrane fibronectin type 3 (FNIII) module. It was found to be expressed in kidney, brain, pancreases, skeletal muscle, lungs, liver placenta and heart3.FLRT3 display a unique multifunctional property acting as chemorepellent by binding to the Netrin receptor Unc5D and regulating radial migration of subventricular progenitors. In addition, it acts as homophilic adhesion molecule regulating the tangential dispersion of migrating neuron progenitors in the developing cortex4. FLRT3 knock out in mice leads to a variety of malformations, like disorganized basement membrane, failure of embryonic turning and ventral body closure, cardiac bifida and asymmetric development of headfolds5.
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基因ID
- 366205
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UniProt
- B1H234
抗原
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