DSCAM 抗体 (Extracellular)
Quick Overview for DSCAM 抗体 (Extracellular) (ABIN7581866)
抗原
See all DSCAM 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 361-377, Extracellular
-
原理
- A Rabbit Polyclonal antibody to L1CAM (extracellular)
-
序列
- (C)RITGLNHANL IMDHMVK
-
特异性
- Extracellular, N-terminus.
-
预测反应
- Rat - identical,Human - 15 out of 17 amino acid residues identical
-
产品特性
- Anti-DSCAM (extracellular) Antibody (ABIN7581866) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize DSCAM from mouse, rat and human samples.
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)RITGLNHANLIMDHMVK, corresponding to amino acid residues 361 - 377 of mouse DSCAM
-
亚型
- IgG
-
-
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (Internal Region) antibody
Verified DSCAM 适用: 人 ELISA, WB, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (AA 301-400) antibodyDSCAM 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (AA 1711-1867) antibodyDSCAM 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (AA 1548-1597) antibodyDSCAM 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (AA 184-271) antibodyDSCAM 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Down Syndrome Cell Adhesion Molecule (DSCAM) (Middle Region) antibodyDSCAM 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠, Pig WB, IP 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300
Application Dilutions Western blot wb: 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 0.2 mL double distilled water (DDW).
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- DSCAM (Down Syndrome Cell Adhesion Molecule (DSCAM))
-
别名
- DSCAM
-
背景
- Down Syndrome Cell Adhesion Molecule, DS Cell Adhesion Molecule, CHD2,Down syndrome cell adhesion molecule, DSCAM, also known as CHD2, is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs). DSCAM is classified as a type I membrane protein with an extracellular domain consisting of ten immunoglobulin (Ig) and six fibronectin type III (FNIII) repeats and an intracellular domain that does not contain any identifiable motifs.1The gene coding for the DSCAM protein is located on the human chromosome 21, specifically in the so-called Down syndrome critical region (DSCR), the trisomy of which is considered a determinant for the intellectual disability associated with Down's syndrome. Therefore, the potential involvement of DSCAM in the developing neural system, has received considerable attention.2,3DSCAM is widely expressed in the vertebrate central nervous system where it plays a crucial role in neural development. DSCAM was found to have a critical role for the development of neural circuits, playing a role in processes such as axon guidance, dendritic arborization, and synapse formation. 2-5DSCAM is involved in axon guidance, a process by which developing neurons extend their axons to establish specific connections with target cells. DSCAM serves as a receptor for Netrin-1, a member of a conserved family of secreted proteins that promote axon outgrowth and guide growth cone navigation.2,6The molecular mechanisms by which DSCAM contributes to autism spectrum disorders (ASDs), is not clear, but it may involve altered synaptic transmission, probably through its interaction with other adhesion molecules such as neuroligins (NLGNs) and neurexin1 (NRXN1). In fact, deletion of DSCAM in neurons results in abnormal spine maturation, altered synaptic transmission, as well as autism-like behaviors.5
-
基因ID
- 13508
-
UniProt
- Q9ERC8
-
途径
- Regulation of Cell Size
抗原
-
