CADM1 抗体 (Extracellular, N-Term)
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Quick Overview for CADM1 抗体 (Extracellular, N-Term) (ABIN7581839)
抗原
See all CADM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 148-163, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to CADM1/SynCAM (extracellular)
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序列
- (C)RNLMIDIQKD TAVEGE
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预测反应
- Rat,human - identical
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产品特性
- Anti-CADM1/SynCAM (extracellular) Antibody (ABIN7581839) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize CADM1 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)RNLMIDIQKDTAVEGE, corresponding to amino acid residues 148 - 163 of mouse CADM1
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亚型
- IgG
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anti-Cell Adhesion Molecule 1 (CADM1) (AA 151-250) antibody
CADM1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 365-442) antibodyCADM1 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 65-160) antibodyCADM1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (Internal Region) antibodyCADM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (C-Term) antibodyCADM1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 45-344) antibodyCADM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 66-94), (N-Term) antibodyCADM1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB22685 unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 27-292) antibodyCADM1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (AA 45-344) antibodyCADM1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Adhesion Molecule 1 (CADM1) (C-Term) antibodyCADM1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:500
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CADM1 (Cell Adhesion Molecule 1 (CADM1))
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别名
- CADM1
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背景
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Synonyms: Cell Adhesion Molecule 1, Synaptic Cell Adhesion Molecule, Nectin-Like 2, NECL-2, Immunoglobulin Superfamily Member 4, IgSF4
Description: SynCAMs are a family of 4 proteins (SynCAM1-4) belonging to the immunoglobulin superfamily of cell adhesion molecules (IgCAMs) and are encoded by the cell adhesion molecule 1-4 (CADM1-4) genes1-3.Evolutionarily, SynCAMs are a fairly recent gene lineage since they are only found in vertebrates1, in contrast to much older synaptogenic adhesion molecules such as neuroligins, which appeared concurrently with the evolution of the first synapses around one billion years ago, or compared to even older protosynaptic adhesion molecules including neurexins and NCAM4.CADM1 (also known as SynCAM1), by far the most studied family member, was identified nearly simultaneously in multiple tissue types and therefore is known by a number of different protein names including immunoglobulin subfamily member 4 (IGSF4)5, spermatogenic immunoglobulin superfamily (SgIGSF)6, and RA1757.CADM1 was also initially discovered as a tumor suppressor gene and termed tumor suppressor in non-small cell lung cancer (TSLC1)8. In fact, CADM1 is downregulated in several tumors including lung, ovarian, hepatocellular carcinoma and glioblastoma, and has been proposed as both a biomarker of malignancy and a therapeutic target9.In addition, CADM1 knockout mice have impaired ultrasonic vocalization, a method for mother-offspring communication, which supports a role for CADM1 in autism spectrum disorders (ASD)10.
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基因ID
- 54725
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UniProt
- Q8R5M8
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation
抗原
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