BST1 抗体 (Extracellular, N-Term)
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Quick Overview for BST1 抗体 (Extracellular, N-Term) (ABIN7581832)
抗原
See all BST1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 129-144, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to C3aR1 (extracellular)
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序列
- (C)KVGDFLSW(S)RQENASG
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预测反应
- Mouse,Rat - 15 out of 16 amino acid residues identical Not recommended for BST1 from human samples
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产品特性
- Anti-CD157/BST1 (extracellular) Antibody (ABIN7581832) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize CD157 from mouse and rat samples. The antibody is not recommended for work with human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KVGDFLSW(S)RQENASG, corresponding to amino acid residues 129 - 144 of mouse BST1
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亚型
- IgG
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anti-Bone Marrow Stromal Cell Antigen 1 (BST1) antibody
BST1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (Internal Region) antibodyBST1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 28-282) antibodyBST1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 63-313) antibodyBST1 适用: 人 WB, ELISA, ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 1-318) antibodyBST1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 1-318) antibodyBST1 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 4C2 unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 29-293) antibodyBST1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 51-150) antibodyBST1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 1 (BST1) (AA 108-157) antibodyBST1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:1000
IP: The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))
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别名
- BST1
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背景
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Synonyms: Bone Marrow Stromal Antigen 1, BST-1, ADP-Ribosyl Cyclase 2, Cyclic ADP-ribose hydrolase 2, CADPr Hydrolase 2, CADPR2, LY-65
Description: CD157, also known as bone marrow stromal cell antigen 1 (BST1), is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein with a dual function as a receptor and a β-NAD+-metabolizing ectoenzyme of the ADP-ribosyl cyclases gene family1.CD157 and its paralog CD38, catalyze the formation of cyclic ADP-ribose (cADPR) from NAD, a second messenger involved in intracellular calcium mobilization through ryanodine receptors, among other functions 1,2.As a receptor, CD157 interacts with β1 and β2 integrins (CD29 and CD18 respectively) to form a multimolecular complex that mediates intracellular signaling through the FAK/Src pathway 1-3. Known ligands for CD157 include extracellular matrix components like fibronectin, fibrinogen, laminin-1 and type 1 collagen 2,3.As it name suggests, CD157 was first identified in bone marrow-derived cells, but it is also expressed in other immune system cells like neutrophils, T-cells, pre B-cells and macrophages. CD157 has been demonstrated to be involved in both the innate and adaptive immune response with roles in B- and T-cell growth and the control of myeloid cells migration during inflammation 1.CD157 is considered a marker and therapeutic target for several hematological malignancies like acute myeloid leukemia (AML) as well as several solid tumors like ovarian and malignant mesothelioma 3,4,5.Outside the immune system, CD157 is expressed in vascular endothelium, intestine and brain among others. Interestingly, CD157, has been identified as a risk factor for neurodegenerative diseases, particularly Parkinson's disease 2,6. The exact role of CD157 in the nervous system is not clear, but it appears to have a role in neurogenesis and neural stem cells proliferation, as well as a role in neuroinflammation probably through its association with CD18 and CD11b 2,7.Finally, studies with CD157 knockout mice, reveal its involvement in depression-like behaviors, social avoidance and anxiety disorders 2,8.
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基因ID
- 12182
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UniProt
- Q64277
抗原
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