LPHN3 抗体 (Extracellular, N-Term)
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Quick Overview for LPHN3 抗体 (Extracellular, N-Term) (ABIN7886548)
抗原
See all LPHN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 572-586, Extracellular, N-Term
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原理
- A Rabbit polyclonal antibody to Latrophilin-3.
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序列
- (C)REIMWFKTRQ GQVAK
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预测反应
- Rat - identical,Human- 14,15 identical
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产品特性
- Anti-Latrophilin-3 (extracellular) Antibody (ABIN7581821) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize Latrophilin-3 from mouse, rat and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)REIMWFKTRQGQVAK, corresponding to amino acid residues 572 - 586 of mouse Latrophilin-3
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亚型
- IgG
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anti-Latrophilin 3 (LPHN3) (AA 1105-1447) antibody
LPHN3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人, 小鼠, 大鼠, 小鸡, 马, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人, 小鼠, 大鼠, 小鸡, 马, 猴, Bat, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (AA 371-397), (N-Term) antibodyLPHN3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB36957 unconjugated
anti-Latrophilin 3 (LPHN3) (Cytoplasmic Domain) antibodyLPHN3 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Latrophilin 3 (LPHN3) (C-Term) antibodyLPHN3 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- The optimal concentration should be determined by the user
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- LPHN3 (Latrophilin 3 (LPHN3))
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别名
- ADGRL3
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背景
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Synonyms: Adhesion G Protein-Coupled Receptor L3, ADGRL3, Calcium-Independent Alpha-Latrotoxin Receptor 3, LPHN3, Lectomedin-3
Description: Latrophilin-3 (LPHN3), also known as ADGRL3, is a member of the adhesion G-protein-coupled receptor (aGPCR) family. This family is characterized by the presence of a GPCR autoproteolysis-inducing (GAIN) domain that facilitates receptor cleavage and activation, along with seven transmembrane domains1,3. LPHN3 is primarily localized to the cell membrane and is prominently expressed in neurons, with high levels observed in brain regions such as the hippocampus and prefrontal cortex1,5. LPHN3 plays critical roles in neuronal development and synapse formation. It mediates its effects through dual mechanisms: coupling with intracellular G-proteins, particularly Gαs and Gα12/13, and recruiting phase-separated postsynaptic protein scaffolds. Activation of LPHN3 is triggered by interactions with its ligands, such as teneurins and FLRTs, which enhance synaptic clustering by promoting scaffold protein condensates. Alternative splicing of Lphn3, studied in mouse models, modulates these pathways, influencing synaptic connectivity and neuronal activity3,4. Biologically, LPHN3 is involved in attention regulation and motor control, with its dysregulation linked to attention deficit hyperactivity disorder (ADHD). Genetic variants in LPHN3 are associated with altered dopaminergic signaling and increased susceptibility to ADHD, as demonstrated in human studies1,2. Furthermore, LPHN3 dysfunction has been implicated in substance use disorders and learning deficits, underscoring its importance in neuropsychiatric and cognitive processes2,5.
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基因ID
- 319387
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UniProt
- Q80TS3
抗原
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