IRS4 抗体 (AA 401-500)
Quick Overview for IRS4 抗体 (AA 401-500) (ABIN726020)
抗原
See all IRS4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 401-500
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from mouse IRS-4
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亚型
- IgG
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anti-Insulin Receptor Substrate 4 (IRS4) (AA 850-950) antibody
IRS4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5B9 unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 633-647) antibodyVerified IRS4 适用: 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (C-Term) antibodyIRS4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 1-196) antibodyIRS4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 4 (IRS4) (AA 1-299) antibodyIRS4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- IRS4 (Insulin Receptor Substrate 4 (IRS4))
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别名
- IRS-4
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背景
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Synonyms: Insulin receptor substrate 4, IRS-4, Phosphoprotein of 160 kDa, pp160
Background: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
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基因ID
- 16370
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UniProt
- Q9Z0Y7
抗原
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