CD172a/b 抗体 (APC)
Quick Overview for CD172a/b 抗体 (APC) (ABIN7566516)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- APC Anti-Human CD172a/b Antibody[SE5A5]
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亚型
- IgG1, kappa
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anti-CD172a/b antibody (PE)
适用: 人 FACS 宿主: 小鼠 Monoclonal SE5A5 PE
anti-CD172a/b antibody (APC)适用: 人 FACS 宿主: 小鼠 Monoclonal SE5A5 APC
anti-CD172a/b antibody适用: 人 FACS 宿主: 小鼠 Monoclonal SE5A5 unconjugated
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应用备注
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Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.
FCM: 5 µL/test -
说明
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Matching Isotype Control: (ABIN7469762)
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.
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储存条件
- 4 °C
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储存方法
- This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
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有效期
- 12 months
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- CD172a/b
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背景
- SIRPa,SIRPb,SIRPalpha/beta,BIT,SHPS1,MFR,P84,PTPNS1,CD172 antigen-like family member A,CD172 antigen-like family member B,CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
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基因ID
- 140885
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UniProt
- O00241
抗原
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