TNFSF13 抗体
Quick Overview for TNFSF13 抗体 (ABIN7566471)
抗原
See all TNFSF13 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- anti-APRIL, mAb (Heaty-1)
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产品特性
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Monoclonal Antibody. Recognizes mouse and human recombinant and endogenous APRIL. Isotype: Mouse IgG2b. Immunogen: Recombinant mouse APRIL. Applications: ELISA, IP. Liquid. In PBS containing 0.02 % Proclin 300. APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.
APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.
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纯化方法
- Puified
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant mouse APRIL.
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亚型
- IgG2b
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (Internal Region) antibody
TNFSF13 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 105-250) antibodyTNFSF13 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 2C2C11 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 105-247) antibodyTNFSF13 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 1-247) antibodyTNFSF13 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal G3 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (Internal Region) antibodyTNFSF13 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 105-250) antibodyTNFSF13 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (Center) antibodyTNFSF13 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 151-200) antibodyTNFSF13 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) antibodyTNFSF13 适用: 人 WB, IP, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal Aprily-8 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13) (AA 105-250) antibodyTNFSF13 适用: Cow FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 0.02 % Proclin 300.
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注意事项
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
Stable for at least 1 year after receipt when stored at -20°C.
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- TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))
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别名
- APRIL
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UniProt
- Q9D777
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
抗原
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