GBP1 抗体
Quick Overview for GBP1 抗体 (ABIN7566425)
抗原
See all GBP1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- anti-GBP1 (human), pAb (IN111)
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产品特性
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Polyclonal antibody. Recognizes endogenous human GBP1. Application: WB. Source: Rabbit. Liquid. In PBS containing 0.05 % sodium azide. Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.
Guanylate-binding proteins (GBPs) are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen (S. Typhimurium or Salmonella), GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS (Lipopolysaccharide) of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.
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纯化方法
- Puified
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纯度
- >95 % (SDS-PAGE)
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免疫原
- Recombinant human GBP1 protein (aa 200-592).
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anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 383-592) antibody
GBP1 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 1-593) antibodyGBP1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4D10 unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 1-592) antibodyGBP1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D10 unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 1-592) antibodyGBP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 1-592) antibodyGBP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (AA 1-592) antibodyGBP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (C-Term) antibodyGBP1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) antibodyGBP1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) (Internal Region) antibodyGBP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanylate Binding Protein 1, Interferon-Inducible (GBP1) antibodyGBP1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- In PBS containing 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
Stable for at least 1 year after receipt when stored at -20°C.
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- GBP1 (Guanylate Binding Protein 1, Interferon-Inducible (GBP1))
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别名
- GBP1
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UniProt
- P32455
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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