MUC4 抗体
Quick Overview for MUC4 抗体 (ABIN7565925)
抗原
See all MUC4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- MUC4 Antibody
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交叉反应 （详细）
- This affinity-purified antibody is directed against human MUC4 protein.
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产品特性
- Synonyms: Rabbit Anti-MUC4 Antibody, Rabbit Anti-Mucin 4 Antibody, MUC4, Mucin-4, Ascites sialoglycoprotein, ASGP, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha chain, Ascites sialoglycoprotein 1, ASGP-1, Mucin-4 beta chain, Ascites sialoglycoprotein 2, ASGP-2, MUC
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of human Mucin-4.
Immunogen Type: Conjugated Peptide
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anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibody
MUC4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 5B12 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC4-3105 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1730-1864) antibodyMUC4 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal MUC4-3084 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1501-1613) antibodyMUC4 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 529-560), (N-Term) antibodyMUC4 适用: 人 WB 宿主: 兔 Polyclonal RB49957 unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 79-188) antibodyMUC4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1154-1309) antibodyMUC4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (N-Term) antibodyMUC4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mucin 4, Cell Surface Associated (MUC4) (AA 1249-1444) antibodyMUC4 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Application Note: Anti-MUC4 Antibody was tested in ELISA, Western Blot, and Immunohistochemistry. Antibodies shows no cross reactivity to non-mucilated proteins. Positive control used in WB were HPAC, HPAF-II, and Capan-2 cell lines and IHC was HPAC cell line. Immunohistochemistry Dilution: 1:1000 Western Blot Dilution: 1:1000 ELISA Dilution: 5 μg/mL
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.0 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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别名
- MUC4
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) (NCI). MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. Highly glycosylated proteins called mucins, are the major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix. MUC4's ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. MUC4 seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. These glycoproteins play an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 Tyr-1248. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a co-receptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. May play a role in tumor progression. MUC4 is associated with diseases such as bile duct cancer, keratitis, adenosquamous carcinoma, and pancreatic adenocarcinomas. Anti-MUC4 Antibody is useful for researchers interested in digestion, cancer research, and extracellular matrix Antibodies.
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基因ID
- 4585
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NCBI登录号
- NP_004523
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UniProt
- Q99102
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途径
- Regulation of Leukocyte Mediated Immunity
抗原
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