Recombinant TCR gamma/delta 抗体
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Quick Overview for Recombinant TCR gamma/delta 抗体 (ABIN7543458)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Gamma Delta TCR [G5-4], Mouse IgG2a, kappa
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特异性
- This antibody is specific for the human TCR delta and gamma chains. The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. On activation through antigen presenting cells (APCs), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. TCR part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing BALB/c mice with recombinant gamma9delta2 (OT3)-Fc fusion protein as an immunogen.
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亚型
- IgG2a kappa
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anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (APC)
TCR gamma/delta 适用: 人 FACS 宿主: 小鼠 Monoclonal 11F2 APC
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (FITC)TCR gamma/delta 适用: 人 FACS 宿主: 小鼠 Monoclonal 11F2 FITC
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (PE)TCR gamma/delta 适用: 人 FACS 宿主: 小鼠 Monoclonal 11F2 PE
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibodyTCR gamma/delta 适用: 大鼠 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal V65 unconjugated
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibodyTCR gamma/delta 适用: 人 FACS, IP, IHC (fro), ELISA 宿主: 小鼠 Monoclonal 11F2 unconjugated
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (PE)TCR gamma/delta 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal V65 PE
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibodyTCR gamma/delta 适用: 大鼠 FACS, IP, IHC (fro), Func 宿主: 小鼠 Monoclonal V65 unconjugated
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (FITC)TCR gamma/delta 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal B1 FITC
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibody (PE)TCR gamma/delta 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal B1 PE
anti-T-Cell Receptor gamma/delta (TCR gamma/delta) antibodyTCR gamma/delta 适用: 人, Non-Human Primate FACS, IHC (fro) 宿主: 小鼠 Monoclonal B1 unconjugated
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应用备注
- The binding of this antibody to γδ T cells was determined using flow cytometry. This antibody can compete with commercially available anti-γδ TCR antibody IMMU510 for binding to gamma-delta T cells. It is proposed that, since there is some competition between the two antibodies, G5-4 binds a similar or identical epitope to IMMU510. In an in vitro proliferation assay, this antibody was reported to positively stimulate the proliferation of γδT cells. The scFv version of this antibody was also reported to stimulate the secretion of cytokines like IFN-γ and TGF-α. G5-4ScFv-amplified γδT cells can effectively kill daudi cells, and the killing efficiency is greater than 85 % when the effect-to-target ratio is 5:1 (CN103130894).
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))
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别名
- Gamma Delta TCR
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背景
- TCR γδ, γδ TCR, TCR GD, GD TCR, TCRg/d, T-cell surface glycoprotein CD3 delta chain, CD3D, T3D, T-cell receptor T3 delta chain, T-cell surface glycoprotein CD3 gamma chain, CD3G, T-cell receptor T3 gamma chain, CD3g, T3G
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UniProt
- P04234, P09693
抗原
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