Recombinant FTH1 抗体
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Quick Overview for Recombinant FTH1 抗体 (ABIN7543447)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Ferritin H [4C9], Rabbit IgG, kappa
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特异性
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This antibody binds human acidic isoferritin. Ferritin is a protein that catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis. Ferritins occur as many isoforms, all of which are composed of various combinations of the two primary subunits, H and L. Acidic isoferritins have high proportions of H subunit.
Application Notes original Clone: The binding specificity of this antibody towards acidic isoferritin, basic isoferritin and human liver ferritin was determined using ELISA. This antibody does not cross react with basic isoferritin and human liver ferritin. The binding affinity of the original mouse IgG1 format of this antibody for acidic isoferritin was reported to be Kd= 4.15 nM. This antibody was used for the immunohistochemical staining of liver tissues of primary hepatic carcinoma (PHC)(PMID: 11604110). This antibody can be used for the identification of acidic isoferritins in a western blot (PMID: 12697395).
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产品特性
- This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing BALB/c mice with acidic isoferritin (AIF) from primary hepatic carcinoma (PHC) tissues.
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亚型
- IgG, kappa
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anti-Ferritin Heavy Chain 1 (FTH1) antibody
KD Validated FTH1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 23GB1835 unconjugated Recombinant Antibody
anti-Ferritin Heavy Chain 1 (FTH1) antibodyKD Validated FTH1 适用: 人 WB 宿主: 兔 Monoclonal 23GB1860 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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OriginalSpeciesName: Mouse
OriginalFormat: IgG1
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- FTH1 (Ferritin Heavy Chain 1 (FTH1))
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别名
- Ferritin H
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背景
- FTH1, FTHL6, AIF, acidic isoferritin, Ferritin heavy chain, Ferritin H subunit
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UniProt
- P02794
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途径
- Transition Metal Ion Homeostasis
抗原
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