Recombinant CD2 抗体 (Extracellular Domain)
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Quick Overview for Recombinant CD2 抗体 (Extracellular Domain) (ABIN7543282)
抗原
See all CD2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 39-50, Extracellular Domain
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原理
- Anti-CD2 [35.1], Rabbit IgG, kappa
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特异性
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This antibody recognizes an epitope on the extracellular domain of the human T cell surface protein Tp50 (CD2) between amino acid residues 39-50. The binding of this antibody does not inhibit the interaction between CD2 and CD58. CD2 is a glycoprotein belonging to the immunoglobulin superfamily. It acts as a specific marker for T lymphocytes, natural killer cells, thymic B cell subsets, and some antigen presenting cells. CD2 interacts with CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Application Notes original Clone: This antibody inhibits T cell proliferative responses and cytotoxicity, but does not inhibit antibody mediated cellular cytotoxicity. This antibody was used in the generation of CD2 targeting ricin A chain-containing immunotoxins (PMID: 2461993). This antibody is capable of immunoprecipitating CD2 antigen form cell lysates (PMID: 8557753). This antibody was also used for the cell cycle analysis of cells along with other antibodies like anti-CD3, anti-CD4, and anti-CD8 using flow cytometry (PMID: 9881968).
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产品特性
- This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing mice with human T lymphocytes that had been activated with phorbol myristic acid (PMA).
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亚型
- IgG, kappa
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anti-CD2 (CD2) (AA 25-140) antibody
CD2 适用: 人, 小鼠 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3D1B4 unconjugated
anti-CD2 (CD2) (AA 25-140) antibodyCD2 适用: 小鼠 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal 3D1E3 unconjugated
anti-CD2 (CD2) antibody (PE)CD2 适用: 人 FACS 宿主: 小鼠 Monoclonal LT2 PE
anti-CD2 (CD2) antibody (PE)CD2 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-65 PE
anti-CD2 (CD2) (AA 1-351) antibodyCD2 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-CD2 (CD2) antibodyCD2 适用: 人 FACS, IF, WB, Func 宿主: 小鼠 Monoclonal 1E7E8-G4 unconjugated
anti-CD2 (CD2) antibody (FITC)CD2 适用: 人 FACS 宿主: 小鼠 Monoclonal LT2 FITC
anti-CD2 (CD2) (N-Term) antibodyCD2 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD2 (CD2) (AA 1-351) antibodyCD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CD2 (CD2) antibodyCD2 适用: 人, Pig, Non-Human Primate FACS, IF, WB 宿主: 小鼠 Monoclonal LFA2-600 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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OriginalSpeciesName: Mouse
OriginalFormat: IgG2a
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD2
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别名
- CD2
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背景
- LFA-2, LFA-3 receptor, SRBC, Rosette receptor, T-cell surface antigen CD2, Erythrocyte receptor, T-cell surface antigen T11/Leu-5
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UniProt
- P06729
抗原
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