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Recombinant XCR1 抗体

XCR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5G7 unconjugated Recombinant Antibody
产品编号 ABIN7543272
发货至: 中国
  • 抗原 See all XCR1 抗体
    XCR1 (Chemokine (C Motif) Receptor 1 (XCR1))
    抗体类型
    Recombinant Antibody
    适用
    • 30
    • 3
    • 1
    • 1
    • 1
    宿主
    • 25
    • 4
    • 4
    小鼠
    克隆类型
    • 27
    • 4
    • 2
    单克隆
    标记
    • 26
    • 3
    • 1
    • 1
    • 1
    • 1
    This XCR1 antibody is un-conjugated
    应用范围
    • 19
    • 16
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS)
    原理
    Anti-XCR1 [5G7], Mouse IgG2b, kappa
    特异性
    This antibody binds human XCR1, more particularly it strongly binds amino acids 'PESTTFFYYDLQ' of the human XCR1. XRC1 is a receptor for chemokines SCYC1 and SCYC2 and expressed on 80 % of CD8+ the dendritic cells. It also acts as a receptor for XCL1/Lymphotactin. It transduces a signal by increasing the intracellular calcium ions level.
    产品特性

    Original Species of Ab: Mouse

    Original Format of Ab: IgG2b

    纯化方法
    Protein A affinity purified
    免疫原
    The original antibody was generated by immunizing XCR1 knockout mice with human XCR1-expressing B300.19 cells mixed with equal volume of GERBU adjuvant.
    克隆位点
    5G7
    亚型
    IgG2b kappa
    Top Product
    Discover our top product XCR1 Primary Antibody
  • 应用备注
    This antibody is capable of binding human XCR1-EGFP-expressing B300.19 cells in a flow cytometry analysis. The determination of the binding epitope of this antibody was done using ELISA (US9371389). This antibody exhibits a significant effect in treating rheumatoid arthritis in the experiment of delayed-type hypersensitivity reaction induced by Mycobacterium butyricum delayed-type hypersensitivity reaction. The neutralizing activity of this antibody against human lymphotactin-induced migration of human XCR1-expressing cells was evaluated by in vitro chemotaxis assay. It was reported that this antibody completely inhibited cell migration at a concentration of about 3 μg/mL (US9371389). The effect of this antibody on ear swelling of DNFB (Dinitrofluorobenzene)-sensitized mice was done and it was reported that this antibody caused significant suppression of ear swelling 24 after induction. This antibody was also reported to show showed a very low reactivity to human CX3CR1-EGFP-expressing B300.19 cells (US9371389). The original antibody with saporin-conjugated secondary antibody showed growth suppression of human XCR1-EGFP-expressing B300.19 cells. The humanized version of this antibody is also available on request (US9371389).
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % Proclin 300.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
  • 抗原
    XCR1 (Chemokine (C Motif) Receptor 1 (XCR1))
    别名
    XCR1 (XCR1 产品)
    背景
    CCXCR1, GPR5, chemokine XC receptor 1, G-protein coupled receptor 5, lymphotactin receptor
    UniProt
    P46094
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