Recombinant Aquaporin 4 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant Aquaporin 4 抗体 (ABIN7543244)
抗原
See all Aquaporin 4 (AQP4) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Anti-Aquaporin 4 [C9401], Mouse IgG2b, kappa
-
特异性
- This antibody recognizes and binds extracellular domains of both the M1 and M23 isoforms of human aquaporin 4 (AQP4), but not mouse aquaporin 4. AQP4 is a water channel expressed on astrocytes throughout the CNS and in skeletal muscle and some epithelial cells outside of the CNS. It plays an important role in brain water homeostasis and in glymphatic solute transport. Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) that is associated with demyelination and neurological deficits in optic nerve, spinal cord and brainstem. Most NMOSD patients are seropositive for IgG autoantibodies (NMO-IgG) directed against extracellular epitopes of aquaporin-4 (AQP4). Prevention of the binding of NMO-IgG, therefore, may alleviate the disease.
-
产品特性
-
Original Species of Ab: Mouse
Original Format of Ab: IgG2b
-
纯化方法
- Protein A affinity purified
-
免疫原
- The original antibody was generated by immunizing an aquaporin 4 knock out mice with human AQP4 as an immunogen expressed on the surface of baculovirus.
-
亚型
- IgG2b kappa
-
-
anti-Aquaporin 4 (AQP4) (AA 271-323) antibody
AQP4 适用: 人, 小鼠, 大鼠 WB, ICC, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 178-317) antibodyAQP4 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C9 unconjugated
anti-Aquaporin 4 (AQP4) (AA 244-323) antibodyAQP4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 295-323), (C-Term) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 253-323) antibodyAQP4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Aquaporin 4 (AQP4) antibodyMicroarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB430199 unconjugated
anti-Aquaporin 4 (AQP4) antibodyMicroarray verified AQP4 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB287702 unconjugated
anti-Aquaporin 4 (AQP4) (AA 258-274) antibodyAQP4 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Aquaporin 4 (AQP4) (AA 178-317) antibodyAQP4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- This antibody binds extracellular domain of human aquaporin 4 with a very high binding affinity. The binding of this antibody inhibits the binding of NMO-IgG to AQP4 (PMID: 23746426). The binding affinity of this antibody for human AQP4 M23 isoform expressed on the surface of baculovirus and CHO cells was tested with ELISA (PMID: 26398585, WO2014196658). The binding characterization of this antibody was done using flow cytometry. This antibody can be used for the immunoprecipitation of human AQP4 but not mouse AQP4 (WO2014196658, PMID: 23909421). This antibody is not suitable for detection of denatured human AQP4 in a western blot assay (WO2014196658).
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- PBS with 0.02 % Proclin 300.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
-
- Aquaporin 4 (AQP4)
-
别名
- Aquaporin 4
-
背景
- AQP4, AQP-4, Aquaporin-4, MIWC, WCH4, Mercurial-insensitive water channel
-
UniProt
- P55087
-
途径
- Sensory Perception of Sound
抗原
-
