Recombinant GDF8 (Lintuzumab Biosimilar) 抗体
The 兔 Chimeric anti-GDF8 (Lintuzumab Biosimilar) antibody (Clone SGN-33) (ABIN7543069) specifically detects GDF8 (Lintuzumab Biosimilar) in Func.
The antibody is reactive with 人 samples.
产品编号 ABIN7543069
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant GDF8 (Lintuzumab Biosimilar) 抗体 (ABIN7543069)
抗原
GDF8 (Lintuzumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
兔
克隆类型
Chimeric
标记
非结合性
应用范围
Functional Studies (Func)
克隆位点
SGN-33
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原理
- Anti-CD33 [SGN-33 (Lintuzumab)], Rabbit IgG, kappa
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特异性
- This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.
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亚型
- IgG kappa
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应用备注
- In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).
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说明
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- GDF8 (Lintuzumab Biosimilar)
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别名
- CD33 (Lintuzumab Biosimilar)
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物质类
- Biosimilar
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背景
- Sialic acid-binding Ig-like lectin 3, gp67, HuM195
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UniProt
- P20138
抗原
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