Recombinant EGFR (Nimotuzumab Biosimilar) 抗体
This anti-EGFR (Nimotuzumab Biosimilar) antibody is a 小鼠 Chimeric antibody detecting EGFR (Nimotuzumab Biosimilar) in BR, FACS 和 IHC. Suitable for 人.
Quick Overview for Recombinant EGFR (Nimotuzumab Biosimilar) 抗体 (ABIN7543062)
抗原
EGFR (Nimotuzumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
Chimeric
标记
This EGFR (Nimotuzumab Biosimilar) antibody is un-conjugated
应用范围
Blocking Reagent (BR), Flow Cytometry (FACS), Immunohistochemistry (IHC)
克隆位点
H-R3
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原理
- Anti-EGFR domain III [h-R3 (Nimotuzumab)], Mouse IgG2a, kappa
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特异性
- Binds to human EGFR domain III at a site distinct from antibody 7A7 (Ab00134) (Talavera et al. 2011)
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody we generated by humanisation of the murine antibody R3, raised against EGFR purified from placenta membranes and A431 tumors.
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亚型
- IgG2a kappa
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应用备注
- This antibody binds to human EGFR and inhibits EGF-dependent clonogenic growth of NRK cells and completely blocks EGF stimulated autophosphorylation of the receptor (Fernandez 1992)
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说明
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- EGFR (Nimotuzumab Biosimilar)
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物质类
- Biosimilar
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背景
- ERBB-D3, ERBB1, HER1, PIG61, mENA, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1, epidermal growth factor
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UniProt
- P00533
抗原
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