Recombinant CD40L (Ruplizumab Biosimilar) 抗体
Quick Overview for Recombinant CD40L (Ruplizumab Biosimilar) 抗体 (ABIN7542960)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG2a, kappa
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特异性
- The antibody binds to CD40L with an IC50 of 0.845 μg/mL.
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产品特性
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Original Species of Ab: Human
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- Human CD40L
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亚型
- IgG2a kappa
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anti-CD40LG (Ruplizumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-CD40LG (Ruplizumab Biosimilar) antibody适用: 人 FACS, WB, BR 宿主: 兔 Chimeric hu5c8 unconjugated Recombinant Antibody
anti-CD40LG (Ruplizumab Biosimilar) antibody适用: 人 FACS, WB, BR 宿主: Human Monoclonal hu5c8 unconjugated Recombinant Antibody
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应用备注
- The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours.
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说明
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This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))
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别名
- CD40L (Ruplizumab Biosimilar)
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物质类
- Biosimilar
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背景
- CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP
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UniProt
- P29965
抗原
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