SHANK3 抗体 (AA 586-626) (FITC)
Quick Overview for SHANK3 抗体 (AA 586-626) (FITC) (ABIN7540503)
抗原
See all SHANK3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 586-626
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Supplier Product No.
- 200-302-w72
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Supplier
- Rockland
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原理
- SHANK1/SHANK3 Antibody Fluorescein
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交叉反应 （详细）
- BLAST analysis suggests that it is 100 % identical to mouse, 97 % identical to human and ~70 % identical to SHANK1 and SHANK2.
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纯化方法
- Anti-SHANK1/SHANK3 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- Anti-SHANK1/SHANK3 Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 586-626 (SH3 domain) of rat SHANK3.
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亚型
- IgG2a
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anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (HRP)
SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 HRP
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (FITC)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 FITC
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (Biotin)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 Biotin
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (PE)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 PE
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (PerCP)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 PerCP
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (APC)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 APC
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (Atto 488)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 Atto 488
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (Atto 594)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 Atto 594
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibody (Atto 390)SHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 Atto 390
anti-SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3) (AA 840-857) antibodySHANK3 适用: 大鼠 WB, IHC, IP, ICC, IF, AA 宿主: 小鼠 Monoclonal S69 unconjugated
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应用备注
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ELISA_Dilution: 1:10,000
Immunohistochemistry_Dilution: User Optimized
Western_Blot_Dilution: 1:1000
Other: ICC/IF: 1:100
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说明
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Anti-SHANK1/SHANK3 FITC Conjugated Antibody is suitable for Western Blots, Immunohistochemistry and Immunocytochemistry. Expect a band approximately ~190kDa on specific lysates or tissues. It will cross react with SHANK1, but it will not cross react with SHANK2. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.1 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- SHANK3 (SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3))
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别名
- Shank3
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背景
- Shank postsynaptic density protein, SH3 and multiple ankyrin repeat domains 3, Proline rich synapse associated protein 2, Proline-rich synapse-associated protein 2, ProSAP2, PSAP2, , SH3 and multiple ankyrin repeat domains protein 3,SHANK proteins are scaffolding adaptors that have been shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. SHANK1-3 of the SHANK/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). SHANK recruits betaPIX and PAK to dendritic spines to regulate postsynaptic structure and interacts with ionotropic receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Anti-SHANK1/SHANK3 is ideal for research in Neuroscience, including autism spectrum disorder, and Cell Adhesion.
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基因ID
- 59312
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UniProt
- Q9JLU4
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途径
- Synaptic Membrane, Tube Formation, Regulation of long-term Neuronal Synaptic Plasticity
抗原
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