TCR V Alpha24-J Alpha18 抗体 (PE)
适用: 人
FACS
宿主: 小鼠
Monoclonal
6B11
PE
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- 抗原
- TCR V Alpha24-J Alpha18
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- PE
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应用范围
- Flow Cytometry (FACS)
- 原理
- Anti-Hu TCR Valpha24-Jalpha18 PE
- 特异性
- The mouse monoclonal antibody 6B11 recognizes an extracellular epitope within V alpha 24 J alpha 18 TCR, which is expressed by invariant NK T cells (iNKT).
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 克隆位点
- 6B11
- 亚型
- IgG1 kappa
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- 抗原
- TCR V Alpha24-J Alpha18
- 别名
- TCR Valpha24-Jalpha18
- 背景
- TCR alpha V24-J18 chain is a marker of invariant NK T cells (iNKT). This chain pairs mostly with TCR beta V11 chain, and together they interact with glycolipide-loaded CD1d. This interaction results in iNKT activation and cytokine production (IFN gamma, IL-4, IL-13), which takes important part in immune regulation and host response to pathogens and cancer(support of both Th1 and Th2 way), although iNKT cells represent less than 1 % of total peripheral T cells.
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