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Geminin 抗体

This 小鼠 单克隆 anti-Geminin antibody (Clone 2H10G3) specifically detects Geminin in IHC, ELISA 和 FACS. The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN7539692
发货至: 中国
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Quick Overview for Geminin 抗体 (ABIN7539692)

抗原

See all Geminin (GMNN) 抗体
Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

适用

  • 75
  • 12
  • 11
人, 大鼠

宿主

  • 55
  • 23
小鼠

克隆类型

  • 42
  • 36
单克隆

标记

  • 38
  • 5
  • 5
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  • 3
  • 2
  • 2
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  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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This Geminin antibody is un-conjugated

应用范围

  • 41
  • 36
  • 32
  • 21
  • 20
  • 11
  • 10
  • 8
  • 3
  • 3
  • 2
  • 1
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  • 1
Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

克隆位点

2H10G3
  • 原理

    GMNN Antibody

    纯化方法

    Purified antibody

    免疫原

    Purified recombinant fragment of human GMNN (AA: FULL 1-209) expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    限制

    仅限研究用
  • 缓冲液

    Purified antibody in PBS with 0.05 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • 抗原

    Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

    别名

    GMNN

    背景

    This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

    分子量

    23.6 kDa

    UniProt

    O75496

    途径

    EGFR Signaling Pathway, DNA Replication
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