Neuropilin 1 抗体
Quick Overview for Neuropilin 1 抗体 (ABIN7539267)
抗原
See all Neuropilin 1 (NRP1) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NRP-1 antibody
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特异性
- Chromosomal location:10p12
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纯化方法
- Protein A purified
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免疫原
- Recombinant human NRP-1 (ABIN7539343)
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anti-Neuropilin 1 (NRP1) (AA 646-814) antibody
NRP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 646-814) antibodyNRP1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Neuropilin 1 (NRP1) (AA 22-131) antibodyNRP1 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-Neuropilin 1 (NRP1) (AA 21-250) antibodyNRP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) antibodyNRP1 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 722-750) antibodyNRP1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 45-59) antibodyNRP1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 5B1E11 unconjugated
anti-Neuropilin 1 (NRP1) (AA 722-750), (C-Term) antibodyNRP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22995 unconjugated
anti-Neuropilin 1 (NRP1) (AA 502-514), (Extracellular) antibodyNRP1 适用: 人 WB, FACS, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Neuropilin 1 (NRP1) (AA 851-923) antibodyNRP1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: Use 1-5 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- Neuropilin 1 (NRP1)
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别名
- NRP-1
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背景
- Neuropilin receptor-1, VEGF165R, NRP, CD304, neuropilin,Neuropilin-1 (NRP-1, CD304) is a 130-140 kDa type I transmembrane glycoprotein that regulates axon guidance and angiogenesis. The human NRP-1 contains a 623 aa extracellular domain (ECD) that shows 92-95 % aa identity with mouse, rat, bovine and canine NRP-1. The ECD contains two N-terminal CUB domains (termed a1a2), two domains with homology to coagulation factors V and VIII (b1b2) and a MAM (meprin) domain. C-terminally divergent splice variants with 704, 644, 609, and 551 aa lack the MAM and TM domains and are demonstrated or presumed to be soluble antagonists. Heparin, the heparin-binding forms of VEGF (VEGF165, VEGF-B, VEGF-E), PlGF-2, and the C-terminus of Sema3 bind the b1b2 region. NRP-1 and NRP-2 share 48 % aa identity within the ECD and can form homo and hetero-oligomers via interaction of their MAM domains. Neuropilins show partially overlapping expression in neuronal and endothelial cells during development. Both neuropilins act as coreceptors with Plexins, mainly Plexin A3 and A4, to bind class III Semaphorins that mediate axon repulsion. However, only NRP-1 binds Sema3A, and only NRP-2 binds Sema 3F. Both are co-receptors with VEGFR-2 (KDR7Flk1) for VEGF165 binding. Sema 3A signaling can be blocked by VEGF165, which has higher affinity for NRP-1. NRP-1 is preferentially expressed in arteries during development or those undergoing remodeling. NRP-1 is also expressed on dendritic cells and mediates DC-induced T-cell proliferation
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基因ID
- 8829
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NCBI登录号
- NM_003873, NP_003864
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UniProt
- O14786
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途径
- Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
抗原
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