Endothelin 1 抗体
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北京 101111
Quick Overview for Endothelin 1 抗体 (ABIN7539247)
抗原
See all Endothelin 1 (EDN1) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Endothelin-1/ET-1 antibody
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纯化方法
- Protein A purified
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anti-Endothelin 1 (EDN1) (AA 33-202) antibody
EDN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelin 1 (EDN1) (AA 53-90) antibodyEDN1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Endothelin 1 (EDN1) (AA 18-212) antibodyEDN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Endothelin 1 (EDN1) (AA 113-212) antibodyEDN1 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 3D6 unconjugated
anti-Endothelin 1 (EDN1) (AA 53-90) antibodyEDN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Endothelin 1 (EDN1) (AA 118-146), (Middle Region) antibodyEDN1 适用: 人 WB, IF, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-Endothelin 1 (EDN1) (AA 53-73) antibodyEDN1 适用: 人, 大鼠, Pig, 小鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Endothelin 1 (EDN1) antibodyEDN1 适用: 人, 大鼠 WB, IF (p), IHC (p) 宿主: 小鼠 Monoclonal 2C4 unconjugated
anti-Endothelin 1 (EDN1) (AA 53-203) antibodyEDN1 适用: Pig WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 5# unconjugated
anti-Endothelin 1 (EDN1) (C-Term) antibodyEDN1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: Use 1-5 μg/mL
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- Endothelin 1 (EDN1)
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别名
- Endothelin-1/ET-1
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背景
- Preproendothelin-1, PPET-1, ET-1, EDN1,Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
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基因ID
- 1906
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NCBI登录号
- NM_01955, NP_001946
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UniProt
- P05305
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途径
- Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Cell Size
抗原
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