Emilin1 抗体
Quick Overview for Emilin1 抗体 (ABIN7539245)
抗原
See all Emilin1 (EMILIN1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Emilin-1 antibody
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纯化方法
- Protein-G purified
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免疫原
- recombinant human Emilin-1
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亚型
- IgG2a
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anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 1-347) antibody
EMILIN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A3 unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 684-899) antibodyEMILIN1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) antibodyEMILIN1 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 84-112), (N-Term) antibodyEMILIN1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18213 unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) antibodyEMILIN1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 1-347) antibodyEMILIN1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 1-347) antibodyEMILIN1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 1-347) antibodyEMILIN1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 806-1016) antibodyEMILIN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Elastin Microfibril Interfacer 1 (EMILIN1) (AA 803-1016) antibodyEMILIN1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
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有效期
- 24 months
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- Emilin1 (EMILIN1) (Elastin Microfibril Interfacer 1 (EMILIN1))
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别名
- Emilin-1
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背景
- Elastin microfibril interface-located protein 1, Elastin microfibril interfacer 1, EMI,Emilins (elastin microfibril interface located proteins) are extracellular matrix glycoproteins that localize to sites with proximity to elastin and microfibrils. They consist of an N-terminal cysteine-rich EMI domain and a conserved C-terminal gC1q-like domain. Emilin-1 is abundant in elastin-rich tissues such as blood vessels, skin, heart and lung. It influences placenta formation and initial organogenesis with a later role in interstitial connective tissue. Emilin-2 is larger than Emilin-1 and contains a unique proline-rich domain. It is likely involved in the process of elastogenesis. Multimerin-2 (also known as Emilin-3 or EndoGlyx-1) is expressed during embryonic development. Multimerin-1 (also known as Emilin-4) is expressed in platelets and the endothelium of blood vessels and may act as a carrier protein for platelet factor V. Emilin-5 is encoded by the Emilin-3 gene and is sometimes referred to as Emilin-3. It contains the N-terminal cysteine-rich EMI domain but lacks the C-terminal gC1q-like domain. Emilin-1 have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 exerts an important role in lymphatic system, being a crucial structural molecule that regulates the formation of lymphatic capillaries and collectors. Emilin-1 through the interaction with the α4β1 integrin via the C-terminal gC1q domain exerts a negative effect on proliferation. It binds pro-TGFβ preventing its maturation to mature TGFβ in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
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基因ID
- 11117
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NCBI登录号
- NM_007046, NP_008977
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UniProt
- Q9Y6C2
抗原
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