S100A1 抗体
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北京 101111
Quick Overview for S100A1 抗体 (ABIN7538098)
抗原
See all S100A1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit polyclonal antibodies to Bovine S100
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特异性
- Specific to all isotypes (alpha:alpha, alpha:beta and beta:beta)
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交叉反应 (详细)
- May cross-react with other species
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纯化方法
- Protein A affinity column
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免疫原
- Native source protein
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亚型
- IgG, IgM
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应用备注
- Western blot: 0.1-1.0 μg/mL
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Glycine pH 7.2
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储存条件
- 4 °C,-80 °C
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储存方法
- Short term up to 1 month at 2-8°C, long term can be held for up to five years at -70°C
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- S100A1 (S100 Calcium Binding Protein A1 (S100A1))
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别名
- S100
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背景
- Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole
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分子量
- 10668 Da (beta), 10518 Da (alpha)
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途径
- Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades, S100 Proteins
抗原
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