Recombinant OC126 (Abagovomab Biosimilar) 抗体
The Human 单克隆 anti-OC126 (Abagovomab Biosimilar) antibody is suitable to detect OC126 (Abagovomab Biosimilar) in samples from 小鼠. It has been validated for ELISA 和 WB.
产品编号 ABIN7538052
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant OC126 (Abagovomab Biosimilar) 抗体 (ABIN7538052)
抗原
OC126 (Abagovomab Biosimilar)
抗体类型
Recombinant Antibody
适用
小鼠
宿主
Human
克隆类型
单克隆
标记
This OC126 (Abagovomab Biosimilar) antibody is un-conjugated
应用范围
ELISA, Western Blotting (WB)
质量等级
Research Grade
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Expression System
- Mammalian cells
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原理
- Abagovomab Biosimilar - Anti-idiotope of anti-Mus musculus monoclonal antibody OC126 mAb - Research Grade
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产品特性
- Antibody Type: idiotypic IgG1-kappa
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纯化方法
- Recombinant antibody expressed in mammalien cells and purified.
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纯度
- > 85%
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亚型
- IgG1 kappa
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限制
- 仅限研究用
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缓冲液
- PBS buffer PH7.5
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储存条件
- -80 °C
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储存方法
- store at -80°C
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- OC126 (Abagovomab Biosimilar)
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物质类
- Biosimilar
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背景
- Abagovomab is a murine monoclonal anti-idiotypic antibody (MW: 165-175 kDa), produced by a mouse hybridoma and generated against OC125, which serves to functionally imitate the human cancer antigen 125 (CA-125). Abagovomab has been developed by the pharmaceutical company Menarini for the treatment of ovarian cancer. It (ab2) shows high affinity for the paratope of ab1, and binding of ab2 to Ab1 is almost completely inhibited (93%) by the nominal antigen. The administration of F(ab')2 fragments of abagovomab to rats produces anti-CA-125 immunity with the production of IgG and IgM anti-anti-idiotypic antibodies (ab3) that bind both to abagovomab and CA-125. Non-MHC restricted cell-mediated cytotoxicity for NIH OVCAR3 cell lines is also demonstrated.
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CAS-编号
- 792921-10-9
抗原
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