TOMM34 抗体
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北京 101111
Quick Overview for TOMM34 抗体 (ABIN7506025)
抗原
See all TOMM34 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-Hu Tomm34 Purified
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特异性
- The mouse monoclonal antibody Tomm34-4.1 recognizes an epitope within TPR2 domain of human Tomm34 protein.
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纯化方法
- Purified by protein-A affinity chromatography.
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免疫原
- Recombinant human Tomm34
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- TOMM34 (Translocase of Outer Mitochondrial Membrane 34 (TOMM34))
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别名
- Tomm34
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背景
- Translocase of outer mitochondrial membrane 34,Tomm34 (translocase of the outer mitochondrial membrane 34) is an additional component of the cellular chaperone system involved in protein folding. As the name suggests, Tomm34 was initially identified as being involved in mitochondrial protein processing. Subsequent studies have shown that Tomm34 interacts with both Hsp70 and Hsp90 and modifies their protein folding activities. In cancer, high levels of Tomm34 have been reported in bladder, colorectal and breast cancers compared to their normal tissue counterparts. In these cancers, Tomm34 promotes colorectal cancer cell growth and is a biomarker of poor outcome in early invasive breast cancer and bladder cancer. As a tumour-associated protein, Tomm34 peptide vaccination is under investigation as a therapeutic option for colorectal cancer, with significant Tomm34 cytotoxic T-lymphocyte (CTL) response observed.,URCC3, HTOM34P
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基因ID
- 10953
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UniProt
- Q15785
抗原
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