SCIMP 抗体 (PE)
This anti-SCIMP antibody is a 小鼠 单克隆 antibody detecting SCIMP in ICFC. Suitable for 人.
Quick Overview for SCIMP 抗体 (PE) (ABIN7506008)
抗原
See all SCIMP 抗体
SCIMP
(SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This SCIMP antibody is conjugated to PE
应用范围
Intracellular Flow Cytometry (ICFC)
克隆位点
NVL-07
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原理
- Anti-SCIMP PE
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特异性
- The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
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纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
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免疫原
- Recombinant intracellular part of human SCIMP
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亚型
- IgG2a
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anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) antibody
SCIMP 适用: 人 IP, WB, ICC, ICFC 宿主: 小鼠 Monoclonal NVL-07 unconjugated
anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) (AA 59-145) antibodySCIMP 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.
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限制
- 仅限研究用
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缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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- SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
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别名
- SCIMP
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背景
- SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL
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基因ID
- 388325
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UniProt
- Q6UWF3
抗原
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