CD79a 抗体
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- 抗原 See all CD79a (CD79A) 抗体
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD79a antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 原理
- Anti-Hu CD79a Purified
- 特异性
- The mouse monoclonal antibody ZL7.4 interacts with extracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- 纯化方法
- Purified by protein-A affinity chromatography.
- 免疫原
- IgM complex isolated from Daudi cells
- 克隆位点
- ZL7-4
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CD79A Primary Antibody
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- 应用备注
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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- 抗原
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
- 别名
- CD79a (CD79A 产品)
- 背景
- CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
- 基因ID
- 973
- UniProt
- P11912
- 途径
- BCR Signaling
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