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SIRPA 抗体 (FITC)

This anti-SIRPA antibody (ABIN7505868) is a Mouse Monoclonal antibody detecting SIRPA in FACS. Suitable for Human.
产品编号 ABIN7505868
发货至: 中国

Quick Overview for SIRPA 抗体 (FITC) (ABIN7505868)

抗原

See all SIRPA 抗体
SIRPA (Signal-Regulatory Protein alpha (SIRPA))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This SIRPA antibody is conjugated to FITC

应用范围

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Flow Cytometry (FACS)

克隆位点

15-414
  • 原理

    Anti-Hu CD172a FITC

    特异性

    The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons.

    纯化方法

    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    免疫原

    Kg-1a cell line

    亚型

    IgG2a
  • 应用备注

    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

    限制

    仅限研究用
  • 缓冲液

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • 抗原

    SIRPA (Signal-Regulatory Protein alpha (SIRPA))

    别名

    CD172a

    背景

    Signal regulatory protein alpha,CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells.,PTPNS1, BIT, MFR, SIRPA, SHPS1

    基因ID

    140885

    UniProt

    P78324
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