Arginine-Gingipain B (RgpB) 抗体
The 小鼠 单克隆 anti-Arginine-Gingipain B (RgpB) antibody is suitable to detect Arginine-Gingipain B (RgpB) in samples from Porphyromonas gingivalis. It has been validated for IHC 和 WB.
产品编号 ABIN7489927
发货至:
中国
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Quick Overview for Arginine-Gingipain B (RgpB) 抗体 (ABIN7489927)
抗原
Arginine-Gingipain B (RgpB)
适用
Porphyromonas gingivalis
宿主
小鼠
克隆类型
单克隆
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
克隆位点
18E6-F7
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特异性
- This antibody recognizes a unique epitope within the immunoglobulin (Ig)-like domain of arginine-gingipain (RgpB).
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交叉反应
- Porphyromonas gingivalis
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免疫原
- Arginine-gingipain B (RgpB) from Porphyromonas gingivalis.
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亚型
- IgG1
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应用备注
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Paraffin-embedded formalin-fixed AD hippocampus and gingival tissue from a patient with periodontal disease stained with #13925 and compared to non-AD control tissue and mouse IgG1 control (see Dominy et al. Science Advances 5 (1): eaau3333).
Detection of RgpB in P. gingivalis wild-type strain W83 whole cells (see Nguyen K-A et al. J Bacteriol 189: 833-843). -
说明
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Anti-Gngipaing B (RgpB) Mouse Monoclonal Antibody
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限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4,Phosphate Buffered Saline
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.
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- Arginine-Gingipain B (RgpB)
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背景
- Gingipain B,Arginine-gingipain B (RgpB) is a cysteine protease produced exclusively by Porphyromonas gingivalis, and it plays a central role in the pathogenicity of P. gingivalis in periodontal disease. Over the last several years, a possible association between Alzheimer disease (AD) and chronic periodontitis has been suggested based on detection of P. gingivalis infiltration in autopsy specimens from the brains of people with AD in association with neurons, tau tangles, and beta-amyloid as well as in cerebrospinal fluid of individuals diagnosed with AD. Oral administration of a gingipain inhibitor to mice with established brain infection by P. gingivalis decreased the amount of P. gingivalis DNA in brain as well as the levels of beta-amyloid and tumor necrosis factor-α. Taken together, the data suggest that gingipain inhibitors might be an effective treatment of AD. Clinical trials of gingipain inhibitors are currently underway.,Arginine-gingipain B
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UniProt
- Q51844
抗原
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