Recombinant PROC 抗体
Quick Overview for Recombinant PROC 抗体 (ABIN7487753)
抗原
See all PROC 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Anti-Protein C [HPC-4], Mouse IgG1, kappa
-
特异性
- Specifically binds to a specific twelve peptide sequence (EDQVDPRLIDGK) in the activation region of the Protein C (spanning the thrombin cleavage site). Does not react with activated protein C. Has been shown to be cross-reactive with baboon Protein C but not with bovine or mouse Protein C.
-
交叉反应
- Baboon
-
产品特性
-
Original Species of Ab: Mouse
Original Format of Ab: IgG1
-
纯化方法
- Protein A affinity purified
-
免疫原
- This antibody was raised by immunising mice with human protein C.
-
亚型
- IgG1 kappa
-
-
anti-Vitamin K-dependent protein C (PROC) (AA 32-131) antibody
PROC 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3A10 unconjugated
anti-Vitamin K-dependent protein C (PROC) antibodyPROC 适用: 人 ELISA, IHC, IHC (p), IEP 宿主: 山羊 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (AA 446-461), (C-Term) antibodyPROC 适用: 人 WB, IHC, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (AA 1-236) antibodyPROC 适用: 人 WB, IHC, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) antibodyPROC 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (Middle Region) antibodyPROC 适用: 人, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) antibodyPROC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (AA 197-436) antibodyPROC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (AA 17-166) antibodyPROC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Vitamin K-dependent protein C (PROC) (AA 288-409) antibodyPROC 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- HPC-4 binds human protein C only in the presence of Ca2+, it binds to the reduced carboxymethylated protein C heavy chain, and it blocks protein C activation but does not bind or inactivate protein C or activated protein C bound to its plasma inhibitor. Furthermore, it is an anti-epitope tag antibody, as it recognizes the EDQVDPRLIDGK sequence (Taylor Jr et al., 1987, 3102560). It has been shown to work in ELISAs to determine expression levels (Velander et al., 1992, PMID: 1465430). HPC-4 has been shown to be effective at purifying proteins tagged with its epitope (Rezaie et al., 1992, PMID: 1283093). It has also been used to block the activation of Protein C by the thrombin-thrombomodulin complex (Stearns et al., 1988, PMID: 2447082) and was used for the same purpose in Baboons to lower the threshold of sepsis (Taylor Jr et al., 1987, PMID: 3102560). HPC-4 has been used in many other studies to observe the function of Protein C by knocking out its function in a Ca2+-dependent manner, purification, and others (Tanaka et al., 2006, PMID: 16398653) (Bae et al., 2007, PMID: 17823308).
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- PBS with 0.02 % Proclin 300.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
-
- PROC (Vitamin K-dependent protein C (PROC))
-
别名
- Protein C
-
背景
- Autoprothrombin IIA, C-tag, Protein C tag, Protein C-tag, HPC4, Vitamin K-dependent protein C, Anticoagulant protein C, Blood coagulation factor XIV, PROC
-
UniProt
- P04070
抗原
-
