Recombinant FCAR 抗体
Quick Overview for Recombinant FCAR 抗体 (ABIN7487710)
抗原
See all FCAR 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD89 [14A8 (14.1)], Rabbit IgG, kappa
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特异性
- This antibody binds CD89 in the extracellular domain 2, outside the IgA-binding site.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG1
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纯化方法
- Protein A affinity purified
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免疫原
- The original antibody was generated by immunizing HCO12 trangene containing mice with recombinant soluble CD89 antigen.
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亚型
- IgG kappa
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anti-Fc Fragment of IgA, Receptor For (FCAR) (AA 22-227) antibody
FCAR 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 2F9D8 unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) (AA 51-280) antibodyFCAR 适用: 大鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) antibodyFCAR 适用: 人 WB, FACS, ELISA, IP 宿主: 小鼠 Monoclonal MIP8a unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) antibodyFCAR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) antibodyFCAR 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal A59 unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) antibody (APC)FCAR 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal A59 APC
anti-Fc Fragment of IgA, Receptor For (FCAR) (AA 131-230) antibodyFCAR 适用: 人, 大鼠 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) (AA 58-84) antibodyFCAR 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) (AA 1-287) antibodyFCAR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Fc Fragment of IgA, Receptor For (FCAR) antibody (FITC)FCAR 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal A59 FITC
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应用备注
- This antibody binds human CD89 with a dissociation constant of Kd= 6.8 X10-10M.The binding of this antibody to human CD89 was confirmed with ELISA. This antibody was also capable of recognizing human CD89 expressing cells like human PMNL cells by flow cytometry. This antibody is not capable of blocking binding of IgA to CD89. This antibody can used to immunoprecipitate soluble CD89 (US7192582). A bispecific antibody construct incorporating the variable regions of the anti-gp41 antibody F240 and the anti-CD89 (immunoglobulin A [IgA] receptor) antibody 14A8 was reported to promote destruction of HIV type 1 (HIV-1) by neutrophils (PMID: 18272577). A Fab-like bispecific antibody molecule or Bi-Fab antibody generated from F240scFv and 14A8scFv showed significant antiboy dependent cell-mediated viral inhibition (ADCVI) activity for multiple clade B and clade C isolates by arming the neutrophils to inhibit HIV infection (PMID: 27419146).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- FCAR (Fc Fragment of IgA, Receptor For (FCAR))
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别名
- CD89
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背景
- Immunoglobulin alpha Fc receptor, FCAR, IgA Fc receptor, FcαR
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UniProt
- P24071
抗原
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