Recombinant CD47 抗体
Quick Overview for Recombinant CD47 抗体 (ABIN7487701)
抗原
See all CD47 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Anti-CD47 [mIAP430], Rabbit IgG, kappa
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特异性
- This antibody recognises CD47 which is a a multitransmembrane glycoprotein widely expressed on all hematopoietic cells and most other cell types. It is involved in cell adhesion, Ca2+ influx, platelet activation and peripheral mononuclear neutrophils migration across endothelial and epithelial monolayers.
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产品特性
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
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纯化方法
- Protein A affinity purified
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免疫原
- This antibody was raised by immunising IAP-deficient mice with purified human placental CD47.
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亚型
- IgG kappa
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应用备注
- This antibody can be used to investigate the role of the CD47 receptor. mIAP430 was first used to visualise the distribution of CD47 on fusing macrophages (Han et al., 2000). Further, it was demonstrated that this antibody can block fusion of macrophages by blocking CD47 and preventing the binding of this receptor with MFR (Han et al., 2000).
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说明
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This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS with 0.02 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- CD47
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别名
- CD47
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背景
- IAP, C5/D5, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, Protein MER6
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UniProt
- Q08722
抗原
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