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MBD3 抗体

The 兔 多克隆 anti-MBD3 antibody (ABIN7469294) specifically detects MBD3 in WB. The antibody is reactive with 人 samples.
产品编号 ABIN7469294
发货至: 中国
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Quick Overview for MBD3 抗体 (ABIN7469294)

抗原

See all MBD3 抗体
MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

适用

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宿主

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克隆类型

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多克隆

标记

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This MBD3 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 交叉反应

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein encompassing a sequence within the center region of human MBD3. The exact sequence is proprietary.

    亚型

    IgG
  • 应用备注

    WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

    说明

    Positive Control: A431 nucleus

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.51 mg/mL

    缓冲液

    1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • 抗原

    MBD3 (Methyl-CpG Binding Domain Protein 3 (MBD3))

    别名

    MBD3

    背景

    Synonyms: methyl-CpG binding domain protein 3

    Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71 % and 94 % identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. [provided by RefSeq]

    分子量

    33 kDa

    基因ID

    53615

    UniProt

    O95983

    途径

    Chromatin Binding
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