TSG101 抗体 (AA 167-374)
Quick Overview for TSG101 抗体 (AA 167-374) (ABIN7469107)
抗原
See all TSG101 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 167-374
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特异性
- Knockdown/Knockout validation was supported by references (PMID:27226592)
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交叉反应
- 犬, Hamster, 人, 猴, 小鼠, Pig, 大鼠, 斑马鱼
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Amino acids 167-374 of TSG101 protein expressed in E. coli.
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亚型
- IgG1
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应用备注
- WB: 1:500-1:3000. ICC/IF: 1:500-1:1000. IHC-P: 1:100-1:1000. FACS: 1:25-1:200. EM: 1:10. IHC: 1:100. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
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说明
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Positive Control: 293T , K562 , THP-1 , HL-60 , Neuro 2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , NIH-3T3 , JC , BCL-1 Validation: KO/KD, Orthogonal, Overexpression, Recombinant antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.8 mg/mL
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缓冲液
- PBS, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
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别名
- tumor susceptibility 101
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背景
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Synonyms: tumor susceptibility 101 , TSG10 , VPS23
Background: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
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分子量
- 44 kDa
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基因ID
- 7251
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UniProt
- Q99816
抗原
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